Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025854354> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3025854354 endingPage "1150" @default.
- W3025854354 startingPage "1141" @default.
- W3025854354 abstract "The study of rare, inherited forms of different diseases resulted in the discovery of gene defects that cause inherited variants of the respective diseases. The defective genes were found to encode major molecular players leading to the neuropathological lesions or factors that characterize these diseases. The exact role of the tau protein in the neurodegenerative process is still under debate. It is very important to understand the normal biological roles of tau and the specific events that induce tau to become neurotoxic. Tau is the major microtubule-associated protein (MAP) of a mature neuron. The other neuronal MAPs are MAP1 and MAP2. These three MAPs perform similar function, promoting assembly and stability of microtubules. Tau protein was isolated as a microtubule-associated factor in the porcine brain. It was isolated as a protein that co-purified with tubulin and had the ability to promote microtubule assembly in vitro. Normal adult human brain tau contains 2-3 moles phosphate÷mole of tau protein. Hyperphosphorylation of tau depress this biological activity of tau. Almost 80 diseases caused by missense mutations and intronic mutations in the tau gene have been found in familial cases of frontotemporal dementia (FTD). In Alzheimer's disease (AD), there are intraneuronal neurofibrillary tangles composed of the microtubule-associated protein tau (MAPT). In other neurodegenerative diseases, there are similar deposits of tau, in the absence of extracellular deposits (progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, etc.). Tau pathology is also often seen in some forms of Parkinson's disease (PD) and prion diseases. In genetic forms of FTD, mutations in tau implicate abnormal tau as the initiation of neurodegeneration. In FTD, there are deposits especially in temporal and frontal lobes, regions that are very important for behavior and executive function. It is critical to understand how tau becomes pathogenic, in order to consider developing any strategies for treatment." @default.
- W3025854354 created "2020-05-21" @default.
- W3025854354 creator A5032749753 @default.
- W3025854354 creator A5034343326 @default.
- W3025854354 creator A5048163717 @default.
- W3025854354 creator A5060044478 @default.
- W3025854354 creator A5064929266 @default.
- W3025854354 creator A5069155030 @default.
- W3025854354 creator A5072767314 @default.
- W3025854354 creator A5074953408 @default.
- W3025854354 date "2017-01-01" @default.
- W3025854354 modified "2023-10-06" @default.
- W3025854354 title "Tau protein in neurodegenerative diseases - a review." @default.
- W3025854354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29556602" @default.
- W3025854354 hasPublicationYear "2017" @default.
- W3025854354 type Work @default.
- W3025854354 sameAs 3025854354 @default.
- W3025854354 citedByCount "30" @default.
- W3025854354 countsByYear W30258543542019 @default.
- W3025854354 countsByYear W30258543542020 @default.
- W3025854354 countsByYear W30258543542021 @default.
- W3025854354 countsByYear W30258543542022 @default.
- W3025854354 countsByYear W30258543542023 @default.
- W3025854354 crossrefType "journal-article" @default.
- W3025854354 hasAuthorship W3025854354A5032749753 @default.
- W3025854354 hasAuthorship W3025854354A5034343326 @default.
- W3025854354 hasAuthorship W3025854354A5048163717 @default.
- W3025854354 hasAuthorship W3025854354A5060044478 @default.
- W3025854354 hasAuthorship W3025854354A5064929266 @default.
- W3025854354 hasAuthorship W3025854354A5069155030 @default.
- W3025854354 hasAuthorship W3025854354A5072767314 @default.
- W3025854354 hasAuthorship W3025854354A5074953408 @default.
- W3025854354 hasConcept C104317684 @default.
- W3025854354 hasConcept C142724271 @default.
- W3025854354 hasConcept C169760540 @default.
- W3025854354 hasConcept C20418707 @default.
- W3025854354 hasConcept C2776477761 @default.
- W3025854354 hasConcept C2776925932 @default.
- W3025854354 hasConcept C2776936178 @default.
- W3025854354 hasConcept C2777739294 @default.
- W3025854354 hasConcept C2778641062 @default.
- W3025854354 hasConcept C2778670691 @default.
- W3025854354 hasConcept C2779134260 @default.
- W3025854354 hasConcept C2779483572 @default.
- W3025854354 hasConcept C2781172350 @default.
- W3025854354 hasConcept C501734568 @default.
- W3025854354 hasConcept C502032728 @default.
- W3025854354 hasConcept C54355233 @default.
- W3025854354 hasConcept C61081601 @default.
- W3025854354 hasConcept C71924100 @default.
- W3025854354 hasConcept C75563809 @default.
- W3025854354 hasConcept C86803240 @default.
- W3025854354 hasConceptScore W3025854354C104317684 @default.
- W3025854354 hasConceptScore W3025854354C142724271 @default.
- W3025854354 hasConceptScore W3025854354C169760540 @default.
- W3025854354 hasConceptScore W3025854354C20418707 @default.
- W3025854354 hasConceptScore W3025854354C2776477761 @default.
- W3025854354 hasConceptScore W3025854354C2776925932 @default.
- W3025854354 hasConceptScore W3025854354C2776936178 @default.
- W3025854354 hasConceptScore W3025854354C2777739294 @default.
- W3025854354 hasConceptScore W3025854354C2778641062 @default.
- W3025854354 hasConceptScore W3025854354C2778670691 @default.
- W3025854354 hasConceptScore W3025854354C2779134260 @default.
- W3025854354 hasConceptScore W3025854354C2779483572 @default.
- W3025854354 hasConceptScore W3025854354C2781172350 @default.
- W3025854354 hasConceptScore W3025854354C501734568 @default.
- W3025854354 hasConceptScore W3025854354C502032728 @default.
- W3025854354 hasConceptScore W3025854354C54355233 @default.
- W3025854354 hasConceptScore W3025854354C61081601 @default.
- W3025854354 hasConceptScore W3025854354C71924100 @default.
- W3025854354 hasConceptScore W3025854354C75563809 @default.
- W3025854354 hasConceptScore W3025854354C86803240 @default.
- W3025854354 hasIssue "4" @default.
- W3025854354 hasLocation W30258543541 @default.
- W3025854354 hasOpenAccess W3025854354 @default.
- W3025854354 hasPrimaryLocation W30258543541 @default.
- W3025854354 hasRelatedWork W2017625002 @default.
- W3025854354 hasRelatedWork W2041922475 @default.
- W3025854354 hasRelatedWork W2072383054 @default.
- W3025854354 hasRelatedWork W2314613554 @default.
- W3025854354 hasRelatedWork W2499579822 @default.
- W3025854354 hasRelatedWork W2799421418 @default.
- W3025854354 hasRelatedWork W3007324781 @default.
- W3025854354 hasRelatedWork W3025854354 @default.
- W3025854354 hasRelatedWork W3120567829 @default.
- W3025854354 hasRelatedWork W56304416 @default.
- W3025854354 hasVolume "58" @default.
- W3025854354 isParatext "false" @default.
- W3025854354 isRetracted "false" @default.
- W3025854354 magId "3025854354" @default.
- W3025854354 workType "article" @default.