FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025855461> ?p ?o ?g. }

• W3025855461 endingPage "998" @default.
• W3025855461 startingPage "988" @default.
• W3025855461 abstract "Purpose: To evaluate the effect of ionizing radiation (IR) exposure on differentiation and maturation of dendritic cells (DC).Materials and methods: Bone marrow progenitor cells irradiated in vitro or isolated from mice exposed to whole body or localized tumor irradiation were differentiated into DC. Phenotypic maturation of DC was characterized by labeling with specific antibodies and flow cytometry analysis. Cytokines were estimated by ELISA.Results: Splenic and bone marrow-derived DC (BMDC) from tumor-bearing mice exposed to localized irradiation showed abrogation of tumor-induced immunosuppression. This was not due to the effect of radiation on tumor cells as DC derived from normal mice exposed to whole-body irradiation (WBI) also showed increase in immune-activating potential of DC. This was observed in terms of increased phenotypic and functional activation of DCs. This phenomenon was also recapitulated if DC were differentiated from in vitro irradiated progenitor cells and was found to be due to STAT5/Zbtb46 signaling mediated by the irradiation-induced apoptotic bodies (ABs). When these ABs were depleted using annexin-beads, these effects were reversed confirming the involvement of this pathway. The role of ABs was further validated in DC derived from mice exposed to WBI in adaptive response experiments with 0.1 Gy priming dose prior to 2 Gy challenge dose. A corresponding reduction in DC maturation markers was observed with decrease in apoptosis in vivo. Further, these DCs derived from irradiated progenitors (IP) could resist the suppressive effects of tumor conditioned medium (TCM) and had increased immune-activating potential as seen in the tumor-bearing mice.Conclusions: Though radiation is the most commonly used therapeutic modality for cancer, its effects on dendritic cell differentiation is not completely understood. We demonstrate here for the first time that exposure to select doses of IR can increase immune-activating potential of DC through ABs. This can have implications in selection of appropriate doses of IR during radiotherapy of cancer patients." @default.
• W3025855461 created "2020-05-21" @default.
• W3025855461 creator A5035779527 @default.
• W3025855461 creator A5049321562 @default.
• W3025855461 date "2020-05-26" @default.
• W3025855461 modified "2023-09-27" @default.
• W3025855461 title "Radiation-induced augmentation in dendritic cell function is mediated by apoptotic bodies/STAT5/Zbtb46 signaling" @default.
• W3025855461 cites W1516647311 @default.
• W3025855461 cites W1560542066 @default.
• W3025855461 cites W1582679620 @default.
• W3025855461 cites W1673487389 @default.
• W3025855461 cites W1856075116 @default.
• W3025855461 cites W1912124796 @default.
• W3025855461 cites W1967771839 @default.
• W3025855461 cites W1973515061 @default.
• W3025855461 cites W1973605050 @default.
• W3025855461 cites W1976261738 @default.
• W3025855461 cites W1979850440 @default.
• W3025855461 cites W1981253936 @default.
• W3025855461 cites W1981743414 @default.
• W3025855461 cites W1983640108 @default.
• W3025855461 cites W1992675784 @default.
• W3025855461 cites W2025421597 @default.
• W3025855461 cites W2032210657 @default.
• W3025855461 cites W2048784307 @default.
• W3025855461 cites W2068557660 @default.
• W3025855461 cites W2075227225 @default.
• W3025855461 cites W2092235636 @default.
• W3025855461 cites W2093424661 @default.
• W3025855461 cites W2103496546 @default.
• W3025855461 cites W2104043654 @default.
• W3025855461 cites W2105243377 @default.
• W3025855461 cites W2108789863 @default.
• W3025855461 cites W2113594480 @default.
• W3025855461 cites W2130590529 @default.
• W3025855461 cites W2142153200 @default.
• W3025855461 cites W2150293352 @default.
• W3025855461 cites W2153432331 @default.
• W3025855461 cites W2153853960 @default.
• W3025855461 cites W2155033435 @default.
• W3025855461 cites W2170240282 @default.
• W3025855461 cites W2488088692 @default.
• W3025855461 cites W2536331209 @default.
• W3025855461 cites W2537531520 @default.
• W3025855461 cites W2584447915 @default.
• W3025855461 cites W2620249134 @default.
• W3025855461 cites W2810413556 @default.
• W3025855461 cites W2886690563 @default.
• W3025855461 cites W2903132588 @default.
• W3025855461 cites W2921466970 @default.
• W3025855461 doi "https://doi.org/10.1080/09553002.2020.1767818" @default.
• W3025855461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32396024" @default.
• W3025855461 hasPublicationYear "2020" @default.
• W3025855461 type Work @default.
• W3025855461 sameAs 3025855461 @default.
• W3025855461 citedByCount "1" @default.
• W3025855461 countsByYear W30258554612023 @default.
• W3025855461 crossrefType "journal-article" @default.
• W3025855461 hasAuthorship W3025855461A5035779527 @default.
• W3025855461 hasAuthorship W3025855461A5049321562 @default.
• W3025855461 hasConcept C109159458 @default.
• W3025855461 hasConcept C185592680 @default.
• W3025855461 hasConcept C190283241 @default.
• W3025855461 hasConcept C201750760 @default.
• W3025855461 hasConcept C203014093 @default.
• W3025855461 hasConcept C2778170410 @default.
• W3025855461 hasConcept C2780007613 @default.
• W3025855461 hasConcept C28328180 @default.
• W3025855461 hasConcept C502942594 @default.
• W3025855461 hasConcept C553184892 @default.
• W3025855461 hasConcept C55493867 @default.
• W3025855461 hasConcept C86803240 @default.
• W3025855461 hasConcept C8891405 @default.
• W3025855461 hasConcept C95444343 @default.
• W3025855461 hasConceptScore W3025855461C109159458 @default.
• W3025855461 hasConceptScore W3025855461C185592680 @default.
• W3025855461 hasConceptScore W3025855461C190283241 @default.
• W3025855461 hasConceptScore W3025855461C201750760 @default.
• W3025855461 hasConceptScore W3025855461C203014093 @default.
• W3025855461 hasConceptScore W3025855461C2778170410 @default.
• W3025855461 hasConceptScore W3025855461C2780007613 @default.
• W3025855461 hasConceptScore W3025855461C28328180 @default.
• W3025855461 hasConceptScore W3025855461C502942594 @default.
• W3025855461 hasConceptScore W3025855461C553184892 @default.
• W3025855461 hasConceptScore W3025855461C55493867 @default.
• W3025855461 hasConceptScore W3025855461C86803240 @default.
• W3025855461 hasConceptScore W3025855461C8891405 @default.
• W3025855461 hasConceptScore W3025855461C95444343 @default.
• W3025855461 hasIssue "8" @default.
• W3025855461 hasLocation W30258554611 @default.
• W3025855461 hasOpenAccess W3025855461 @default.
• W3025855461 hasPrimaryLocation W30258554611 @default.
• W3025855461 hasRelatedWork W1977841877 @default.
• W3025855461 hasRelatedWork W2008532188 @default.
• W3025855461 hasRelatedWork W2027927113 @default.
• W3025855461 hasRelatedWork W2038236544 @default.
• W3025855461 hasRelatedWork W2093570808 @default.
• W3025855461 hasRelatedWork W2353616266 @default.

• next