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• W3025857586 endingPage "444" @default.
• W3025857586 startingPage "428" @default.
• W3025857586 abstract "Knowing phylogenetic relationships among species is fundamental for many studies in biology. An accurate phylogenetic tree underpins our understanding of the major transitions in evolution, such as the emergence of new body plans or metabolism, and is key to inferring the origin of new genes, detecting molecular adaptation, understanding morphological character evolution and reconstructing demographic changes in recently diverged species. Although data are ever more plentiful and powerful analysis methods are available, there remain many challenges to reliable tree building. Here, we discuss the major steps of phylogenetic analysis, including identification of orthologous genes or proteins, multiple sequence alignment, and choice of substitution models and inference methodologies. Understanding the different sources of errors and the strategies to mitigate them is essential for assembling an accurate tree of life." @default.
• W3025857586 created "2020-05-21" @default.
• W3025857586 creator A5000160233 @default.
• W3025857586 creator A5073515441 @default.
• W3025857586 creator A5074431478 @default.
• W3025857586 date "2020-05-18" @default.
• W3025857586 modified "2023-10-14" @default.
• W3025857586 title "Phylogenetic tree building in the genomic age" @default.
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