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- W3025869425 abstract "Searching biologically active compounds has been one of the major duties of organic chemists. We previously constructed a library of synthetic 12-arylbenzoacridines and found estrogenic and anti-estrogenic agents. With taking the shot-gun approach into consideration, further exploration for bioactive species in the above library was carried out. As a result, new antibacterial agents against S. aureus (MIC = 16 μM), E. coli (MIC = 7.8 μM), E. faecalis (MIC = 0.98 μM), and A. baumannii (MIC = 31 μM) were found. Moreover, we also unveiled that some of the tested compounds exhibit cell-based anti-oxidative activity. These results clearly show a good potential of 12-arylbenzoacridines as novel pharmacophores, which is useful to establish various medicines." @default.
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- W3025869425 date "2020-07-18" @default.
- W3025869425 modified "2023-10-03" @default.
- W3025869425 title "Antimicrobial and Anti-Oxidative Activities of 12-Arylbenzoacridines" @default.
- W3025869425 doi "https://doi.org/10.22146/ijc.53411" @default.
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