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• W3025871009 abstract "Numerous preclinical studies have demonstrated the potential neuroprotective effects of N-acetylcysteine (NAC) in the treatment of brain ischemia. Accordingly, the present study aimed to assess the potential therapeutic effects of oral NAC in patients with acute ischemic stroke.In a randomized, double-blind, placebo-controlled trial study, 68 patients with acute ischemic stroke with the onset of symptoms less than 24 hours were randomly assigned to either the NAC-treated group or placebo-treated group. NAC and matched placebo were administrated by a 72-hour oral protocol (initially 4 grams loading dose and after on, 4 g in 4 equal divided doses for more 2 days). The primary outcomes were quantification of any neurologic deficit by the use of the National Institute of Health Stroke Scale (NIHSS) score and functional disability by the use of the modified Rankin scale (mRS) at 90 days after stroke. Additionally, serum levels of markers of oxidative stress and inflammation as a main mechanism of its action were assessed at baseline and the end of 3-day treatment protocol.NAC-treated patients in comparison with placebo-treated patients showed a significantly lower mean NIHSS scores at day 90 after stroke. A favorable functional outcome which was defined as an mRS score of 0 or 1, also in favor of NAC compared to placebo was noted on day 90 after stroke (57.6% in the NAC-treated group compared with 28.6% in the placebo-treated group). Further, compared to the placebo, NAC treatment significantly decreased serum levels of proinflammatory biomarkers such as interleukin 6 (IL-6), soluble intercellular cell adhesion molecule-1 (sICAM-1), nitric oxide (NO), malondialdehyde (MDA), and neuron-specific enolase (NSE) and significantly increased serum levels of anti-oxidant biomarkers such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and total thiol groups (TTG).The pattern of results suggests that oral NAC administration early after an acute ischemic stroke is associated with a better outcome profile in terms of acute neurological deficit and disability grade compared to placebo. NAC may improve neurological outcomes of patients with stroke at least in part by its antioxidant and anti-inflammatory effects." @default.
• W3025871009 created "2020-05-21" @default.
• W3025871009 creator A5020162735 @default.
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• W3025871009 creator A5038023983 @default.
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• W3025871009 creator A5086747321 @default.
• W3025871009 date "2020-05-01" @default.
• W3025871009 modified "2023-10-18" @default.
• W3025871009 title "<p>Evidence for a Beneficial Effect of Oral N-acetylcysteine on Functional Outcomes and Inflammatory Biomarkers in Patients with Acute Ischemic Stroke</p>" @default.
• W3025871009 cites W107502543 @default.
• W3025871009 cites W1595933188 @default.
• W3025871009 cites W1792160104 @default.
• W3025871009 cites W1966257841 @default.
• W3025871009 cites W1969661146 @default.
• W3025871009 cites W1973253054 @default.
• W3025871009 cites W1973309192 @default.
• W3025871009 cites W1984406225 @default.
• W3025871009 cites W1993228662 @default.
• W3025871009 cites W1994790055 @default.
• W3025871009 cites W1997307168 @default.
• W3025871009 cites W2001113682 @default.
• W3025871009 cites W2004471275 @default.
• W3025871009 cites W2006370393 @default.
• W3025871009 cites W2007137051 @default.
• W3025871009 cites W2008576439 @default.
• W3025871009 cites W2008996296 @default.
• W3025871009 cites W2012140230 @default.
• W3025871009 cites W2016391008 @default.
• W3025871009 cites W2016597337 @default.
• W3025871009 cites W2025501637 @default.
• W3025871009 cites W2029893677 @default.
• W3025871009 cites W2029939842 @default.
• W3025871009 cites W2036575831 @default.
• W3025871009 cites W2037954427 @default.
• W3025871009 cites W2040250889 @default.
• W3025871009 cites W2041021891 @default.
• W3025871009 cites W2042482256 @default.
• W3025871009 cites W2045185962 @default.
• W3025871009 cites W2047279924 @default.
• W3025871009 cites W2047554110 @default.
• W3025871009 cites W2053007566 @default.
• W3025871009 cites W2053244223 @default.
• W3025871009 cites W2053593008 @default.
• W3025871009 cites W2058823140 @default.
• W3025871009 cites W2066189463 @default.
• W3025871009 cites W2069170558 @default.
• W3025871009 cites W2069424573 @default.
• W3025871009 cites W2080857282 @default.
• W3025871009 cites W2081519995 @default.
• W3025871009 cites W2082366457 @default.
• W3025871009 cites W2083004303 @default.
• W3025871009 cites W2086189875 @default.
• W3025871009 cites W2086727094 @default.
• W3025871009 cites W2096190607 @default.
• W3025871009 cites W2099839877 @default.
• W3025871009 cites W2103009454 @default.
• W3025871009 cites W2108430327 @default.
• W3025871009 cites W2116657972 @default.
• W3025871009 cites W2118200665 @default.
• W3025871009 cites W2118575289 @default.
• W3025871009 cites W2118901526 @default.
• W3025871009 cites W2119624946 @default.
• W3025871009 cites W2119701105 @default.
• W3025871009 cites W2122020125 @default.
• W3025871009 cites W2123739790 @default.
• W3025871009 cites W2124107177 @default.
• W3025871009 cites W2124828104 @default.
• W3025871009 cites W2127091487 @default.
• W3025871009 cites W2127157208 @default.
• W3025871009 cites W2128968009 @default.
• W3025871009 cites W2134088303 @default.
• W3025871009 cites W2135605048 @default.
• W3025871009 cites W2137129707 @default.
• W3025871009 cites W2143981013 @default.
• W3025871009 cites W2150565441 @default.
• W3025871009 cites W2153046019 @default.
• W3025871009 cites W2157997761 @default.
• W3025871009 cites W2160213908 @default.
• W3025871009 cites W2161188379 @default.
• W3025871009 cites W2169079203 @default.
• W3025871009 cites W2324553845 @default.
• W3025871009 cites W2480805616 @default.
• W3025871009 cites W2492645699 @default.
• W3025871009 cites W2613135848 @default.
• W3025871009 cites W2753969831 @default.
• W3025871009 cites W2765996079 @default.
• W3025871009 cites W2799611204 @default.
• W3025871009 cites W2801928995 @default.
• W3025871009 cites W2802050234 @default.
• W3025871009 cites W2892546761 @default.
• W3025871009 cites W2900341519 @default.
• W3025871009 cites W2982303713 @default.
• W3025871009 doi "https://doi.org/10.2147/ndt.s241497" @default.
• W3025871009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7244239" @default.
• W3025871009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32547030" @default.
• W3025871009 hasPublicationYear "2020" @default.
• W3025871009 type Work @default.

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