FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025891596> ?p ?o ?g. }

• W3025891596 endingPage "101575" @default.
• W3025891596 startingPage "101575" @default.
• W3025891596 abstract "AMP-activated protein kinase (AMPK) is a cellular energy sensor activated during energy stress to stimulate ATP production pathways and restore homeostasis. AMPK is widely expressed in the kidney and involved in mitochondrial protection and biogenesis upon acute renal ischemia, AMPK activity being blunted in metabolic disease-associated kidney disease. Since little is known about AMPK in the regulation of renal blood flow, the present study aimed to assess the role of AMPK in renal vascular function. Functional responses to the selective AMPK activator A769662 were assessed in intrarenal small arteries isolated from the kidney of renal tumour patients and Wistar rats and mounted in microvascular myographs to perform simultaneous measurements of intracellular calcium [Ca2+]i and tension. Superoxide (O2.-) and hydrogen peroxide (H2O2) production were measured by chemiluminescence and fluorescence and protein expression by Western blot. Activation of AMPK with A769662 increased AMPKα phosphorylation at Thr-172 and induced potent relaxations compared to AICAR in isolated human and rat intrarenal arteries, through both endothelium-dependent mechanisms involving nitric oxide (NO) and intermediate-conductance calcium-activated potassium (IKCa) channels, as well as activation of ATP-sensitive (KATP) channels and sarcoplasmic reticulum Ca2+-ATPase (SERCA) in vascular smooth muscle (VSM). Furthermore, AMPK activator reduced NADPH oxidase 4 (Nox4) and Nox2-derived reactive oxygen species (ROS) production. These results demonstrate that A769662 has potent vasodilator and antioxidant effects in intrarenal arteries. The benefits of AMPK activation in rat kidney are reproduced in human arteries and therefore vascular AMPK activation might be a therapeutic target in the treatment of metabolic disease-associated kidney injury." @default.
• W3025891596 created "2020-05-21" @default.
• W3025891596 creator A5009842537 @default.
• W3025891596 creator A5016224747 @default.
• W3025891596 creator A5022738765 @default.
• W3025891596 creator A5028809564 @default.
• W3025891596 creator A5030302921 @default.
• W3025891596 creator A5031135111 @default.
• W3025891596 creator A5039673509 @default.
• W3025891596 creator A5040864474 @default.
• W3025891596 creator A5045447593 @default.
• W3025891596 creator A5057839161 @default.
• W3025891596 creator A5084649684 @default.
• W3025891596 date "2020-07-01" @default.
• W3025891596 modified "2023-10-18" @default.
• W3025891596 title "Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation" @default.
• W3025891596 cites W1566806909 @default.
• W3025891596 cites W1602687822 @default.
• W3025891596 cites W1827587211 @default.
• W3025891596 cites W1964266642 @default.
• W3025891596 cites W1965430847 @default.
• W3025891596 cites W1966152414 @default.
• W3025891596 cites W1966733021 @default.
• W3025891596 cites W1967892892 @default.
• W3025891596 cites W1972816816 @default.
• W3025891596 cites W1973768018 @default.
• W3025891596 cites W1993984702 @default.
• W3025891596 cites W1995050574 @default.
• W3025891596 cites W2016752484 @default.
• W3025891596 cites W2027108488 @default.
• W3025891596 cites W2033349405 @default.
• W3025891596 cites W2035075611 @default.
• W3025891596 cites W2038424551 @default.
• W3025891596 cites W2046616002 @default.
• W3025891596 cites W2049368067 @default.
• W3025891596 cites W2057218469 @default.
• W3025891596 cites W2071994249 @default.
• W3025891596 cites W2075752867 @default.
• W3025891596 cites W2082866035 @default.
• W3025891596 cites W2085558309 @default.
• W3025891596 cites W2086610472 @default.
• W3025891596 cites W2091263181 @default.
• W3025891596 cites W2096250721 @default.
• W3025891596 cites W2097668381 @default.
• W3025891596 cites W2101540167 @default.
• W3025891596 cites W2104517040 @default.
• W3025891596 cites W2106460275 @default.
• W3025891596 cites W2106919088 @default.
• W3025891596 cites W2110174113 @default.
• W3025891596 cites W2111072772 @default.
• W3025891596 cites W2111298748 @default.
• W3025891596 cites W2114798850 @default.
• W3025891596 cites W2117748926 @default.
• W3025891596 cites W2129470711 @default.
• W3025891596 cites W2135083563 @default.
• W3025891596 cites W2135814736 @default.
• W3025891596 cites W2138226825 @default.
• W3025891596 cites W2138792619 @default.
• W3025891596 cites W2143950284 @default.
• W3025891596 cites W2159235836 @default.
• W3025891596 cites W2162075561 @default.
• W3025891596 cites W2168169323 @default.
• W3025891596 cites W2169143571 @default.
• W3025891596 cites W2169384785 @default.
• W3025891596 cites W2293900380 @default.
• W3025891596 cites W2402553346 @default.
• W3025891596 cites W2519369640 @default.
• W3025891596 cites W2588108588 @default.
• W3025891596 cites W2597137467 @default.
• W3025891596 cites W2620374183 @default.
• W3025891596 cites W2727251727 @default.
• W3025891596 cites W2885299959 @default.
• W3025891596 cites W2901291807 @default.
• W3025891596 doi "https://doi.org/10.1016/j.redox.2020.101575" @default.
• W3025891596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7256643" @default.
• W3025891596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32470915" @default.
• W3025891596 hasPublicationYear "2020" @default.
• W3025891596 type Work @default.
• W3025891596 sameAs 3025891596 @default.
• W3025891596 citedByCount "31" @default.
• W3025891596 countsByYear W30258915962021 @default.
• W3025891596 countsByYear W30258915962022 @default.
• W3025891596 countsByYear W30258915962023 @default.
• W3025891596 crossrefType "journal-article" @default.
• W3025891596 hasAuthorship W3025891596A5009842537 @default.
• W3025891596 hasAuthorship W3025891596A5016224747 @default.
• W3025891596 hasAuthorship W3025891596A5022738765 @default.
• W3025891596 hasAuthorship W3025891596A5028809564 @default.
• W3025891596 hasAuthorship W3025891596A5030302921 @default.
• W3025891596 hasAuthorship W3025891596A5031135111 @default.
• W3025891596 hasAuthorship W3025891596A5039673509 @default.
• W3025891596 hasAuthorship W3025891596A5040864474 @default.
• W3025891596 hasAuthorship W3025891596A5045447593 @default.
• W3025891596 hasAuthorship W3025891596A5057839161 @default.
• W3025891596 hasAuthorship W3025891596A5084649684 @default.
• W3025891596 hasBestOaLocation W30258915961 @default.
• W3025891596 hasConcept C126322002 @default.
• W3025891596 hasConcept C134018914 @default.

• next