FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025896162> ?p ?o ?g. }

• W3025896162 endingPage "3374" @default.
• W3025896162 startingPage "3367" @default.
• W3025896162 abstract "Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Recently, zolbetuximab, a highly potent and tumor cell-selective therapeutic antibody against claudin 18.2, has been developed and investigated in clinical trials.We conducted a prospective study using claudin 18.2 immunohistochemistry in 430 consecutive patients with advanced gastrointestinal, genitourinary, or rare cancers between June 2012 and March 2016.Claudin 18.2 expression was evaluated in 96.3% of the patients (414/430) using immunohistochemistry. In total, 4.1% (17/414) of the patients were claudin 18.2-positive, including patients with pancreatic (16.7%, 1/6), gastric (14.1%, 12/85), biliary tract (6.3%, 1/16), genitourinary/miscellaneous (2.2%, 1/46), and colorectal (0.9%, 2/203) cancers. Twelve of 17 patients positive for claudin 18.2 had gastric cancers (GCs); this subgroup showed no statistical differences by gender, age, disease extent, primary tumor site, pathologic differentiation, human epidermal growth factor receptor 2, or Epstein-Barr virus status with or without claudin 18.2 expression. However, claudin 18.2 was more frequently positive in intestinal-type compared with diffuse-type as assessed by Lauren classification (P=0.026). There was no significant difference in overall survival (OS) between patients with and without claudin 18.2 expression (P=0.101).Our results add to the emerging literature about claudin 18.2 expression in various cancer types and support the need for extended clinical exploration of zolbetuximab." @default.
• W3025896162 created "2020-05-21" @default.
• W3025896162 creator A5005933314 @default.
• W3025896162 creator A5013311116 @default.
• W3025896162 creator A5014451544 @default.
• W3025896162 creator A5015598872 @default.
• W3025896162 creator A5019406140 @default.
• W3025896162 creator A5026351538 @default.
• W3025896162 creator A5045587524 @default.
• W3025896162 creator A5057146015 @default.
• W3025896162 creator A5065244228 @default.
• W3025896162 creator A5072048377 @default.
• W3025896162 date "2020-05-01" @default.
• W3025896162 modified "2023-10-04" @default.
• W3025896162 title "Claudin 18.2 expression in various tumor types and its role as a potential target in advanced gastric cancer" @default.
• W3025896162 cites W1554042779 @default.
• W3025896162 cites W1601662735 @default.
• W3025896162 cites W1896779049 @default.
• W3025896162 cites W1926327739 @default.
• W3025896162 cites W1995548919 @default.
• W3025896162 cites W2004723568 @default.
• W3025896162 cites W2007895431 @default.
• W3025896162 cites W2011475127 @default.
• W3025896162 cites W2036123840 @default.
• W3025896162 cites W2040882582 @default.
• W3025896162 cites W2041455809 @default.
• W3025896162 cites W2051409356 @default.
• W3025896162 cites W2062398517 @default.
• W3025896162 cites W2066088895 @default.
• W3025896162 cites W2073897377 @default.
• W3025896162 cites W2091774407 @default.
• W3025896162 cites W2105535336 @default.
• W3025896162 cites W2107375736 @default.
• W3025896162 cites W2108902851 @default.
• W3025896162 cites W2124318163 @default.
• W3025896162 cites W2125372085 @default.
• W3025896162 cites W2150267721 @default.
• W3025896162 cites W2161613881 @default.
• W3025896162 cites W2170505336 @default.
• W3025896162 cites W2172070031 @default.
• W3025896162 cites W2809428231 @default.
• W3025896162 cites W2946770750 @default.
• W3025896162 cites W2955746156 @default.
• W3025896162 cites W96996464 @default.
• W3025896162 doi "https://doi.org/10.21037/tcr-19-1876" @default.
• W3025896162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35117702" @default.
• W3025896162 hasPublicationYear "2020" @default.
• W3025896162 type Work @default.
• W3025896162 sameAs 3025896162 @default.
• W3025896162 citedByCount "13" @default.
• W3025896162 countsByYear W30258961622021 @default.
• W3025896162 countsByYear W30258961622022 @default.
• W3025896162 countsByYear W30258961622023 @default.
• W3025896162 crossrefType "journal-article" @default.
• W3025896162 hasAuthorship W3025896162A5005933314 @default.
• W3025896162 hasAuthorship W3025896162A5013311116 @default.
• W3025896162 hasAuthorship W3025896162A5014451544 @default.
• W3025896162 hasAuthorship W3025896162A5015598872 @default.
• W3025896162 hasAuthorship W3025896162A5019406140 @default.
• W3025896162 hasAuthorship W3025896162A5026351538 @default.
• W3025896162 hasAuthorship W3025896162A5045587524 @default.
• W3025896162 hasAuthorship W3025896162A5057146015 @default.
• W3025896162 hasAuthorship W3025896162A5065244228 @default.
• W3025896162 hasAuthorship W3025896162A5072048377 @default.
• W3025896162 hasBestOaLocation W30258961621 @default.
• W3025896162 hasConcept C121608353 @default.
• W3025896162 hasConcept C126322002 @default.
• W3025896162 hasConcept C133507102 @default.
• W3025896162 hasConcept C142724271 @default.
• W3025896162 hasConcept C143998085 @default.
• W3025896162 hasConcept C177779419 @default.
• W3025896162 hasConcept C204232928 @default.
• W3025896162 hasConcept C502942594 @default.
• W3025896162 hasConcept C51872919 @default.
• W3025896162 hasConcept C526805850 @default.
• W3025896162 hasConcept C71924100 @default.
• W3025896162 hasConcept C86803240 @default.
• W3025896162 hasConcept C90924648 @default.
• W3025896162 hasConcept C95444343 @default.
• W3025896162 hasConceptScore W3025896162C121608353 @default.
• W3025896162 hasConceptScore W3025896162C126322002 @default.
• W3025896162 hasConceptScore W3025896162C133507102 @default.
• W3025896162 hasConceptScore W3025896162C142724271 @default.
• W3025896162 hasConceptScore W3025896162C143998085 @default.
• W3025896162 hasConceptScore W3025896162C177779419 @default.
• W3025896162 hasConceptScore W3025896162C204232928 @default.
• W3025896162 hasConceptScore W3025896162C502942594 @default.
• W3025896162 hasConceptScore W3025896162C51872919 @default.
• W3025896162 hasConceptScore W3025896162C526805850 @default.
• W3025896162 hasConceptScore W3025896162C71924100 @default.
• W3025896162 hasConceptScore W3025896162C86803240 @default.
• W3025896162 hasConceptScore W3025896162C90924648 @default.
• W3025896162 hasConceptScore W3025896162C95444343 @default.
• W3025896162 hasIssue "5" @default.
• W3025896162 hasLocation W30258961621 @default.
• W3025896162 hasLocation W30258961622 @default.
• W3025896162 hasLocation W30258961623 @default.
• W3025896162 hasOpenAccess W3025896162 @default.

• next