Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025897174> ?p ?o ?g. }
- W3025897174 abstract "Abstract It is well established that pluripotent stem cells in fetal and postnatal liver (LPCs) can differentiate into both hepatocytes and cholangiocytes. However, the signaling pathways implicated in the differentiation of LPCs are still incompletely understood. Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is known to be involved in osteoblast and myeloid differentiation, but its role in lineage commitment in the liver has not been investigated. Here we show that during development and upon regeneration TFEB drives the differentiation status of murine LPCs into the progenitor/cholangiocyte lineage while inhibiting hepatocyte differentiation. Genetic interaction studies show that Sox9 , a marker of precursor and biliary cells, is a direct transcriptional target of TFEB and a primary mediator of its effects on liver cell fate. In summary, our findings identify an unexplored pathway that controls liver cell lineage commitment and whose dysregulation may play a role in biliary cancer." @default.
- W3025897174 created "2020-05-21" @default.
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- W3025897174 date "2020-05-18" @default.
- W3025897174 modified "2023-10-11" @default.
- W3025897174 title "TFEB regulates murine liver cell fate during development and regeneration" @default.
- W3025897174 cites W1490154674 @default.
- W3025897174 cites W1593612940 @default.
- W3025897174 cites W1678795445 @default.
- W3025897174 cites W176224146 @default.
- W3025897174 cites W1915704240 @default.
- W3025897174 cites W1926788264 @default.
- W3025897174 cites W1968856828 @default.
- W3025897174 cites W1975200363 @default.
- W3025897174 cites W1982237050 @default.
- W3025897174 cites W1982635732 @default.
- W3025897174 cites W1985755271 @default.
- W3025897174 cites W1989749181 @default.
- W3025897174 cites W1989969354 @default.
- W3025897174 cites W1991098379 @default.
- W3025897174 cites W1999286197 @default.
- W3025897174 cites W1999556488 @default.
- W3025897174 cites W2002583936 @default.
- W3025897174 cites W2016820768 @default.
- W3025897174 cites W2017200989 @default.
- W3025897174 cites W2018143149 @default.
- W3025897174 cites W2020541351 @default.
- W3025897174 cites W2028593002 @default.
- W3025897174 cites W2032537363 @default.
- W3025897174 cites W2040738308 @default.
- W3025897174 cites W2046447620 @default.
- W3025897174 cites W2047763468 @default.
- W3025897174 cites W2058315462 @default.
- W3025897174 cites W2063920469 @default.
- W3025897174 cites W2067520027 @default.
- W3025897174 cites W2077499130 @default.
- W3025897174 cites W2078184757 @default.
- W3025897174 cites W2079518314 @default.
- W3025897174 cites W2082699771 @default.
- W3025897174 cites W2084074847 @default.
- W3025897174 cites W2084446191 @default.
- W3025897174 cites W2085778840 @default.
- W3025897174 cites W2095876709 @default.
- W3025897174 cites W2099755414 @default.
- W3025897174 cites W2106607408 @default.
- W3025897174 cites W2106771547 @default.
- W3025897174 cites W2109478314 @default.
- W3025897174 cites W2114104545 @default.
- W3025897174 cites W2115109074 @default.
- W3025897174 cites W2116505693 @default.
- W3025897174 cites W2116634113 @default.
- W3025897174 cites W2125842849 @default.
- W3025897174 cites W2130410032 @default.
- W3025897174 cites W2132886417 @default.
- W3025897174 cites W2138035159 @default.
- W3025897174 cites W2139280965 @default.
- W3025897174 cites W2139948451 @default.
- W3025897174 cites W2147242549 @default.
- W3025897174 cites W2150470627 @default.
- W3025897174 cites W2153188271 @default.
- W3025897174 cites W2158868913 @default.
- W3025897174 cites W2170989872 @default.
- W3025897174 cites W2285174330 @default.
- W3025897174 cites W2373301705 @default.
- W3025897174 cites W2387356591 @default.
- W3025897174 cites W2399977797 @default.
- W3025897174 cites W2523569146 @default.
- W3025897174 cites W2535622376 @default.
- W3025897174 cites W2565398910 @default.
- W3025897174 cites W2594673441 @default.
- W3025897174 cites W2626522201 @default.
- W3025897174 cites W2734880494 @default.
- W3025897174 cites W2792158423 @default.
- W3025897174 cites W2800092117 @default.
- W3025897174 cites W2801786525 @default.
- W3025897174 cites W2808974142 @default.
- W3025897174 cites W2883442429 @default.
- W3025897174 cites W2907960662 @default.
- W3025897174 cites W2946006429 @default.
- W3025897174 cites W2991839464 @default.
- W3025897174 cites W4232337555 @default.
- W3025897174 cites W4250857731 @default.