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• W3025930186 startingPage "122134" @default.
• W3025930186 abstract "Monoclonal antibodies (mAbs) constitute one of the most important and fastest growing sector within the pharmaceutical industry. The variety of different formats and the large molecule sizes of the mAbs result in an inherent complexity. In addition, the posttranslational modifications (PTMs) that can occur during production, formulation and storage pose a major analytical challenge for their characterization. These PTMs may affect the safety, efficacy and/or pharmacokinetic profile of the medicinal product. Therefore, strict quality and stability monitoring, in particular of (potentially) critical quality attributes (CQAs), is mandatory. Focusing on these needs, a toolbox for different approaches of peptide mapping in the routine quality control (QC) environment was developed. This toolbox includes an automated sample preparation with an optimized buffer system in combination with a Single Quad LC-MS system, which provides the flexibility to handle a high-throughput workflow. Our results demonstrate that a Single Quad LC-MS system is suitable for a routine work environment to monitor modifications by using a user-friendly system." @default.
• W3025930186 created "2020-05-21" @default.
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• W3025930186 date "2020-07-01" @default.
• W3025930186 modified "2023-10-16" @default.
• W3025930186 title "Monitoring modifications in biopharmaceuticals: Toolbox for a generic and robust high-throughput quantification method" @default.
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• W3025930186 doi "https://doi.org/10.1016/j.jchromb.2020.122134" @default.
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