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• W3025932015 endingPage "625" @default.
• W3025932015 startingPage "611" @default.
• W3025932015 abstract "Both brain and peripheral cells can synthesize 5-HT from the essential amino acid tryptophan, although intestinal enteroendocrine cells produce the most substantial amount of this hormone in the human body. The serotonergic system encompasses a range of elements required for its synthesis, storage, release, transport, signaling, and degradation, from which it modulates essential functions in keeping with the body homeostasis. Genetic, behavioral, or environmental factors may deregulate the serotonergic system functions, promoting a significant number of pathological conditions. This has been expanded to include different types of cancer. A deregulated serotonergic system may be related to the development of colorectal cancer, because it can either promote or inhibit tumorigenesis in the colon through a combined modulation of DNA repair mechanisms and immune response. Serotonin (5-HT) has complex effects on the central nervous system (CNS), neuroendocrine mechanisms, immunological reactions, intestinal microbiome, and cancer. It has been associated with more severe signs and symptoms of colitis, as well as promoting colorectal cancer (CRC) cells toward expansion. However, recent findings revealed that impairments in 5-HT synthesis lead to high levels of DNA damage in colonocytes, which is linked with inflammatory reactions promoting the development of CRC. Here, we review the diverse roles of 5-HT in intestinal homeostasis and in CRC and discuss how improved understanding of the modulation of the 5-HT pathway could be helpful for the design of novel anticancer therapies. Serotonin (5-HT) has complex effects on the central nervous system (CNS), neuroendocrine mechanisms, immunological reactions, intestinal microbiome, and cancer. It has been associated with more severe signs and symptoms of colitis, as well as promoting colorectal cancer (CRC) cells toward expansion. However, recent findings revealed that impairments in 5-HT synthesis lead to high levels of DNA damage in colonocytes, which is linked with inflammatory reactions promoting the development of CRC. Here, we review the diverse roles of 5-HT in intestinal homeostasis and in CRC and discuss how improved understanding of the modulation of the 5-HT pathway could be helpful for the design of novel anticancer therapies." @default.
• W3025932015 created "2020-05-21" @default.
• W3025932015 creator A5004696064 @default.
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• W3025932015 creator A5039371456 @default.
• W3025932015 creator A5055217845 @default.
• W3025932015 date "2020-08-01" @default.
• W3025932015 modified "2023-10-01" @default.
• W3025932015 title "The Dual Role of Serotonin in Colorectal Cancer" @default.
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