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• W3025952652 abstract "Evolution is a powerful force that can be experimentally harnessed to gain insight into how populations evolve in response to selective pressures. Herein we tested the applicability of experimental evolutionary approaches to gain insight into how the major human pathogen Streptococcus pneumoniae responds to repeated colonization events using a murine model. These studies revealed the population dynamics of repeated colonization events and demonstrated that in vivo experimental evolution resulted in highly reproducible trajectories that reflect the environmental niche encountered during nasal colonization. Mutations impacting the surface charge of the bacteria were repeatedly selected during colonization and provided a fitness benefit in this niche that was counterbalanced by a corresponding fitness defect during lung infection. These data indicate that experimental evolution can be applied to models of pathogenesis to gain insight into organism-specific tissue tropisms." @default.
• W3025952652 created "2020-05-21" @default.
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• W3025952652 date "2020-06-30" @default.
• W3025952652 modified "2023-10-17" @default.
• W3025952652 title "Experimental Evolution <i>In Vivo</i> To Identify Selective Pressures during Pneumococcal Colonization" @default.
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• W3025952652 doi "https://doi.org/10.1128/msystems.00352-20" @default.
• W3025952652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7219553" @default.
• W3025952652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32398278" @default.
• W3025952652 hasPublicationYear "2020" @default.
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