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- W3025967559 endingPage "R574" @default.
- W3025967559 startingPage "R565" @default.
- W3025967559 abstract "Comparative genomics reveals an unexpected diversity in the molecular mechanisms underlying conserved cellular functions, such as DNA replication and cytokinesis. However, the genetic bases and evolutionary processes underlying this 'molecular diversity' remain to be explained. Here, we review a tool to generate alternative mechanisms for conserved cellular functions and test hypotheses concerning the generation of molecular diversity - evolutionary repair experiments, in which laboratory microbial populations adapt in response to a genetic perturbation. We summarize the insights gained from evolutionary repair experiments, the spectrum and dynamics of compensatory mutations, and the alternative molecular mechanisms used to repair perturbed cellular functions. We relate these experiments to the modifications of conserved functions that have occurred outside the laboratory. We end by proposing strategies to improve evolutionary repair experiments as a tool to explore the molecular diversity of life." @default.
- W3025967559 created "2020-05-21" @default.
- W3025967559 creator A5011453758 @default.
- W3025967559 creator A5020634412 @default.
- W3025967559 creator A5049993863 @default.
- W3025967559 creator A5075865279 @default.
- W3025967559 date "2020-05-01" @default.
- W3025967559 modified "2023-10-12" @default.
- W3025967559 title "Evolutionary Repair Experiments as a Window to the Molecular Diversity of Life" @default.
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