FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025981505> ?p ?o ?g. }

• W3025981505 endingPage "2705" @default.
• W3025981505 startingPage "2697" @default.
• W3025981505 abstract "Angiogenesis plays important roles in pathological conditions such as cancer and inflammation as well as normal tissue development and homeostasis. Here, we investigated the effects and molecular mechanisms of α‐viniferin, an oligostilbene isolated from Caragana sinica , on human umbilical vein endothelial cell responses in vitro and angiogenic sprouting in aortic rings ex vivo. α‐viniferin treatment inhibited mitogen‐induced HUVEC proliferation by retinoblastoma protein hypophosphorylation. In addition, α‐viniferin suppressed mitogen‐induced HUVEC adhesion, migration, invasion, and microvessel outgrowth. These anti‐angiogenic activities of α‐viniferin might be mediated through downregulation of cell cycle‐related proteins, vascular endothelial growth factor receptor‐2 (VEGFR‐2), and matrix metalloproteinase‐2. Furthermore, inactivation of VEGFR‐2/p70 ribosomal S6 kinase signaling pathway was found to be involved in α‐viniferin‐mediated modulation of endothelial cell responses. Our results demonstrate the pharmacological functions and molecular mechanisms of α‐viniferin in regulating angiogenesis, suggesting the therapeutic potential of α‐viniferin to treat and prevent various angiogenesis‐related diseases." @default.
• W3025981505 created "2020-05-21" @default.
• W3025981505 creator A5003995797 @default.
• W3025981505 creator A5006446407 @default.
• W3025981505 creator A5018144441 @default.
• W3025981505 creator A5019489608 @default.
• W3025981505 creator A5057487181 @default.
• W3025981505 creator A5062917574 @default.
• W3025981505 creator A5087067952 @default.
• W3025981505 date "2020-05-12" @default.
• W3025981505 modified "2023-10-18" @default.
• W3025981505 title "A novel role for α‐viniferin in suppressing angiogenesis by blocking the<scp>VEGFR</scp>‐2/<scp>p70^S6K</scp>signaling pathway" @default.
• W3025981505 cites W1679229092 @default.
• W3025981505 cites W1972568719 @default.
• W3025981505 cites W1975727775 @default.
• W3025981505 cites W1979011467 @default.
• W3025981505 cites W1981612052 @default.
• W3025981505 cites W198985488 @default.
• W3025981505 cites W1991305397 @default.
• W3025981505 cites W1996810856 @default.
• W3025981505 cites W2000292756 @default.
• W3025981505 cites W2007489508 @default.
• W3025981505 cites W2008239768 @default.
• W3025981505 cites W2012063336 @default.
• W3025981505 cites W2017018900 @default.
• W3025981505 cites W2028415754 @default.
• W3025981505 cites W2028825060 @default.
• W3025981505 cites W2029245342 @default.
• W3025981505 cites W2032995169 @default.
• W3025981505 cites W2036691369 @default.
• W3025981505 cites W2043609246 @default.
• W3025981505 cites W2053221827 @default.
• W3025981505 cites W2054227402 @default.
• W3025981505 cites W2058829665 @default.
• W3025981505 cites W2059669097 @default.
• W3025981505 cites W2067309205 @default.
• W3025981505 cites W2074196937 @default.
• W3025981505 cites W2079843091 @default.
• W3025981505 cites W2082717309 @default.
• W3025981505 cites W2088242042 @default.
• W3025981505 cites W2139551550 @default.
• W3025981505 cites W2142325703 @default.
• W3025981505 cites W2156113162 @default.
• W3025981505 cites W2160444874 @default.
• W3025981505 cites W2166156136 @default.
• W3025981505 cites W2170172431 @default.
• W3025981505 cites W2171852242 @default.
• W3025981505 cites W2171998177 @default.
• W3025981505 cites W2593816418 @default.
• W3025981505 cites W2598750908 @default.
• W3025981505 cites W2793323124 @default.
• W3025981505 doi "https://doi.org/10.1002/ptr.6706" @default.
• W3025981505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32400050" @default.
• W3025981505 hasPublicationYear "2020" @default.
• W3025981505 type Work @default.
• W3025981505 sameAs 3025981505 @default.
• W3025981505 citedByCount "2" @default.
• W3025981505 countsByYear W30259815052022 @default.
• W3025981505 crossrefType "journal-article" @default.
• W3025981505 hasAuthorship W3025981505A5003995797 @default.
• W3025981505 hasAuthorship W3025981505A5006446407 @default.
• W3025981505 hasAuthorship W3025981505A5018144441 @default.
• W3025981505 hasAuthorship W3025981505A5019489608 @default.
• W3025981505 hasAuthorship W3025981505A5057487181 @default.
• W3025981505 hasAuthorship W3025981505A5062917574 @default.
• W3025981505 hasAuthorship W3025981505A5087067952 @default.
• W3025981505 hasConcept C104202773 @default.
• W3025981505 hasConcept C104317684 @default.
• W3025981505 hasConcept C123012128 @default.
• W3025981505 hasConcept C127561419 @default.
• W3025981505 hasConcept C146285616 @default.
• W3025981505 hasConcept C14858245 @default.
• W3025981505 hasConcept C167734588 @default.
• W3025981505 hasConcept C185592680 @default.
• W3025981505 hasConcept C202751555 @default.
• W3025981505 hasConcept C2777025900 @default.
• W3025981505 hasConcept C2777411675 @default.
• W3025981505 hasConcept C2780394083 @default.
• W3025981505 hasConcept C502942594 @default.
• W3025981505 hasConcept C55493867 @default.
• W3025981505 hasConcept C62112901 @default.
• W3025981505 hasConcept C62478195 @default.
• W3025981505 hasConcept C75217442 @default.
• W3025981505 hasConcept C86803240 @default.
• W3025981505 hasConcept C95444343 @default.
• W3025981505 hasConceptScore W3025981505C104202773 @default.
• W3025981505 hasConceptScore W3025981505C104317684 @default.
• W3025981505 hasConceptScore W3025981505C123012128 @default.
• W3025981505 hasConceptScore W3025981505C127561419 @default.
• W3025981505 hasConceptScore W3025981505C146285616 @default.
• W3025981505 hasConceptScore W3025981505C14858245 @default.
• W3025981505 hasConceptScore W3025981505C167734588 @default.
• W3025981505 hasConceptScore W3025981505C185592680 @default.
• W3025981505 hasConceptScore W3025981505C202751555 @default.
• W3025981505 hasConceptScore W3025981505C2777025900 @default.
• W3025981505 hasConceptScore W3025981505C2777411675 @default.
• W3025981505 hasConceptScore W3025981505C2780394083 @default.
• W3025981505 hasConceptScore W3025981505C502942594 @default.

• next