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- W3025984824 abstract "The synthesis of N-hydroxyacetaminophen (N-acetyl-N-hydroxy-p-aminophenol, 4), a postulated toxic metabolite of acetaminophen (N-acetyl-p-aminophenol, 3), and its phenolic sulfate conjugate (potassium N-acetyl-N-hydroxy-p-aminophenyl sulfate) (13) is described. Potassium p-nitrophenyl sulfate was reduced to the hydroxylamine, acetylated, and treated with sulfatase to yield N-hydroxyacetaminophen. The structures assigned are supported by the spectral data (IR, UV, MS, 1H NMR, and 13C NMR). N-Hydroxyacetaminophen was found to be moderately unstable at physiological pH and temperature, whereas it phenolic sulfate conjugate was stable." @default.
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- W3025984824 date "1978-12-12" @default.
- W3025984824 modified "2023-09-27" @default.
- W3025984824 title "ChemInform Abstract: SYNTHESIS OF N-HYDROXYACETAMINOPHEN, A POSTULATED TOXIC METABOLITE OF ACETAMINOPHEN, AND ITS PHENOLIC SULFATE CONJUGATE" @default.
- W3025984824 cites W2012730063 @default.
- W3025984824 doi "https://doi.org/10.1002/chin.197850156" @default.
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