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- W3025995355 endingPage "118741" @default.
- W3025995355 startingPage "118741" @default.
- W3025995355 abstract "Tumor susceptibility gene 101 (TSG101), an ESCRT-I protein, is implicated in multiple cellular processes and its functional depletion can lead to blocked lysosomal degradation, cell cycle arrest, demyelination and neurodegeneration. Here, we show that loss of TSG101 results in endoplasmic reticulum (ER) stress and this causes ER membrane remodelling (EMR). This correlates with an expansion of ER, increased vacuolation, altered relative distribution of the rough and smooth ER and disruption of three-way junctions. Blocked lysosomal degradation due to TSG101 depletion leads to ER stress and Ca2+ leakage from ER stores, causing destabilization of actin cytoskeleton. Inhibiting Ca2+ release from the ER by blocking ryanodine receptors (RYRs) with Dantrolene partially rescues the ER stress phenotypes. Hence, in this study we have identified the involvement of TSG101 in modulating ER stress mediated remodelling by engaging the actin cytoskeleton. This is significant because functional depletion of TSG101 effectuates ER-stress, perturbs the structure, mobility and function of the ER, all aspects closely associated with neurodegenerative diseases. We show that tumor susceptibility gene (TSG) 101 regulates endoplasmic reticulum (ER) stress and its membrane remodelling. Loss of TSG101 perturbs structure, mobility and function of the ER as a consequence of actin destabilization." @default.
- W3025995355 created "2020-05-21" @default.
- W3025995355 creator A5008430529 @default.
- W3025995355 creator A5029896069 @default.
- W3025995355 creator A5031211533 @default.
- W3025995355 creator A5046227511 @default.
- W3025995355 creator A5059944109 @default.
- W3025995355 creator A5067972666 @default.
- W3025995355 date "2020-09-01" @default.
- W3025995355 modified "2023-10-02" @default.
- W3025995355 title "Loss of tumor susceptibility gene 101 (TSG101) perturbs endoplasmic reticulum structure and function" @default.
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