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• W3026031004 abstract "The implications of COVID-19 are wide-ranging for specialties such as rheumatology in which immunomodulatory therapies are prescribed. There has been much trepidation among many healthcare professionals regarding the best course of management during this time. This pandemic has also left many national policy makers perplexed because of our limited knowledge of the effects of COVID-19 in patients with rheumatic disease. Such limitations have resulted in variable evolving guidance among rheumatologists around the globe. The British Society of Rheumatology (BSR) has recently published guidance to help stratify patients according to their level of risk and advise self-isolation or shielding measures for patients in high-risk groups1. Patients are advised to pause immunomodulation [except glucocorticoids (GC), hydroxychloroquine (HCQ), and sulfasalazine (SSZ)] if symptoms consistent with COVID-19 infection develop and to discuss re-initiation of therapy with their rheumatology team. The potential for the virus to persist subclinically in some individuals for an extended period of time after symptom resolution leaves a degree of apprehension among healthcare professionals regarding restarting therapy when an individual becomes asymptomatic. Other European societies, for example the Spanish Society of Rheumatology (SSR), similarly do not specify a time frame for restarting therapy, whereas the American College of Rheumatology (ACR) recommend re-initiation following a negative COVID-19 test or 2 weeks after symptom resolution2,3. The ACR, unlike the BSR, recommends temporary cessation of SSZ if infective symptoms develop, and also suggest cessation of nonsteroidal antiinflammatory drugs (NSAID), which differs from other international recommendations3. Although the SSR does not specify the continuation of HCQ, it notes that this, as well as other drugs [e.g., interleukin 6 (IL-6) or IL-1 and Janus kinase (JAK) inhibitors)] may be continued depending on local protocols2; similarly, the ACR suggests that IL-6 inhibitors may be continued in some … Address correspondence to Dr. H. Jethwa, Addenbrookes’ Hospital, Cambridge CB2 0QQ, UK. Email: hannahjethwa{at}nhs.net." @default.
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• W3026031004 date "2020-05-18" @default.
• W3026031004 modified "2023-09-30" @default.
• W3026031004 title "COVID-19 and Immunomodulatory Therapy — Can We Use Data from Previous Viral Pandemics?" @default.
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• W3026031004 doi "https://doi.org/10.3899/jrheum.200527" @default.
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