FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026095689> ?p ?o ?g. }

• W3026095689 abstract "Cell-autonomous immunity relies on the rapid detection of invasive pathogens by host proteins. Guanylate binding proteins (GBPs) have emerged as key mediators of vertebrate immune defense through their ability to recognize a diverse array of intracellular pathogens and pathogen-containing cellular compartments. Human and mouse GBPs have been shown to target distinct groups of microbes, although the molecular determinants of pathogen specificity remain unclear. We show that rapid diversification of a C-terminal polybasic motif (PBM) in primate GBPs controls recognition of the model cytosolic bacterial pathogen Shigella flexneri By swapping this membrane-binding motif between primate GBP orthologs, we found that the ability to target S. flexneri has been enhanced and lost in specific lineages of New World primates. Single substitutions in rapidly evolving sites of the GBP1 PBM are sufficient to abolish or restore bacterial detection abilities, illustrating a role for epistasis in the evolution of pathogen recognition. We further demonstrate that the squirrel monkey GBP2 C-terminal domain recently gained the ability to target S. flexneri through a stepwise process of convergent evolution. These findings reveal a mechanism by which accelerated evolution of a PBM shifts GBP target specificity and aid in resolving the molecular basis of GBP function in cell-autonomous immune defense.IMPORTANCE Many infectious diseases are caused by microbes that enter and survive within host cells. Guanylate binding proteins (GBPs) are a group of immune proteins which recognize and inhibit a variety of intracellular pathogenic microbes. We discovered that a short sequence within GBPs required for the detection of bacteria, the polybasic motif (PBM), has been rapidly evolving between primate species. By swapping PBMs between primate GBP1 genes, we were able to show that specific sequences can both reduce and improve the ability of GBP1 to target intracellular bacteria. We also show that the ability to envelop bacteria has independently evolved in GBP2 of South American monkeys. Taking the results together, this report illustrates how primate GBPs have adapted to defend against infectious pathogens." @default.
• W3026095689 created "2020-05-29" @default.
• W3026095689 creator A5000338517 @default.
• W3026095689 creator A5007841044 @default.
• W3026095689 creator A5011644914 @default.
• W3026095689 creator A5028579363 @default.
• W3026095689 creator A5033927939 @default.
• W3026095689 creator A5086308905 @default.
• W3026095689 date "2020-06-30" @default.
• W3026095689 modified "2023-10-16" @default.
• W3026095689 title "A Rapidly Evolving Polybasic Motif Modulates Bacterial Detection by Guanylate Binding Proteins" @default.
• W3026095689 cites W1821300684 @default.
• W3026095689 cites W1968426638 @default.
• W3026095689 cites W1972726560 @default.
• W3026095689 cites W1973288627 @default.
• W3026095689 cites W1974784632 @default.
• W3026095689 cites W1984632540 @default.
• W3026095689 cites W1986642565 @default.
• W3026095689 cites W1989889573 @default.
• W3026095689 cites W1995835195 @default.
• W3026095689 cites W1996875120 @default.
• W3026095689 cites W2008771438 @default.
• W3026095689 cites W2014045664 @default.
• W3026095689 cites W2021736427 @default.
• W3026095689 cites W2045493291 @default.
• W3026095689 cites W2058235794 @default.
• W3026095689 cites W2065127848 @default.
• W3026095689 cites W2080722894 @default.
• W3026095689 cites W2085283900 @default.
• W3026095689 cites W2104945145 @default.
• W3026095689 cites W2110335151 @default.
• W3026095689 cites W2120167579 @default.
• W3026095689 cites W2125518460 @default.
• W3026095689 cites W2132629607 @default.
• W3026095689 cites W2133773386 @default.
• W3026095689 cites W2138468602 @default.
• W3026095689 cites W2144368480 @default.
• W3026095689 cites W2144820135 @default.
• W3026095689 cites W2147755399 @default.
• W3026095689 cites W2169886642 @default.
• W3026095689 cites W2191476384 @default.
• W3026095689 cites W2304458632 @default.
• W3026095689 cites W2310060842 @default.
• W3026095689 cites W2373811009 @default.
• W3026095689 cites W2413147630 @default.
• W3026095689 cites W2464961930 @default.
• W3026095689 cites W2588948193 @default.
• W3026095689 cites W2701613709 @default.
• W3026095689 cites W2761436821 @default.
• W3026095689 cites W2762751213 @default.
• W3026095689 cites W2763785504 @default.
• W3026095689 cites W2766729051 @default.
• W3026095689 cites W2767985110 @default.
• W3026095689 cites W2781938185 @default.
• W3026095689 cites W2785555044 @default.
• W3026095689 cites W2810201809 @default.
• W3026095689 cites W2822640846 @default.
• W3026095689 cites W2883058246 @default.
• W3026095689 cites W2901073394 @default.
• W3026095689 cites W2914381860 @default.
• W3026095689 cites W2925201894 @default.
• W3026095689 cites W2951327882 @default.
• W3026095689 cites W2952595944 @default.
• W3026095689 cites W2978782758 @default.
• W3026095689 doi "https://doi.org/10.1128/mbio.00340-20" @default.
• W3026095689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7240152" @default.
• W3026095689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32430466" @default.
• W3026095689 hasPublicationYear "2020" @default.
• W3026095689 type Work @default.
• W3026095689 sameAs 3026095689 @default.
• W3026095689 citedByCount "16" @default.
• W3026095689 countsByYear W30260956892020 @default.
• W3026095689 countsByYear W30260956892021 @default.
• W3026095689 countsByYear W30260956892022 @default.
• W3026095689 countsByYear W30260956892023 @default.
• W3026095689 crossrefType "journal-article" @default.
• W3026095689 hasAuthorship W3026095689A5000338517 @default.
• W3026095689 hasAuthorship W3026095689A5007841044 @default.
• W3026095689 hasAuthorship W3026095689A5011644914 @default.
• W3026095689 hasAuthorship W3026095689A5028579363 @default.
• W3026095689 hasAuthorship W3026095689A5033927939 @default.
• W3026095689 hasAuthorship W3026095689A5086308905 @default.
• W3026095689 hasBestOaLocation W30260956893 @default.
• W3026095689 hasConcept C104317684 @default.
• W3026095689 hasConcept C153726182 @default.
• W3026095689 hasConcept C2776460866 @default.
• W3026095689 hasConcept C2781217973 @default.
• W3026095689 hasConcept C54355233 @default.
• W3026095689 hasConcept C547475151 @default.
• W3026095689 hasConcept C70721500 @default.
• W3026095689 hasConcept C79879829 @default.
• W3026095689 hasConcept C86803240 @default.
• W3026095689 hasConcept C8891405 @default.
• W3026095689 hasConcept C95444343 @default.
• W3026095689 hasConceptScore W3026095689C104317684 @default.
• W3026095689 hasConceptScore W3026095689C153726182 @default.
• W3026095689 hasConceptScore W3026095689C2776460866 @default.
• W3026095689 hasConceptScore W3026095689C2781217973 @default.
• W3026095689 hasConceptScore W3026095689C54355233 @default.
• W3026095689 hasConceptScore W3026095689C547475151 @default.

• next