Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026108885> ?p ?o ?g. }
- W3026108885 abstract "Abstract Knockout of the golgin giantin leads to skeletal and craniofacial defects driven by poorly studied changes in glycosylation and extracellular matrix deposition. Here, we sought to determine how giantin impacts the production of healthy bone tissue by focussing on the main protein component of the osteoid, type I collagen. Giantin mutant zebrafish accumulate multiple spontaneous fractures in their caudal fin, suggesting their bones may be more brittle. Inducing new experimental fractures revealed defects in the mineralisation of newly deposited collagen as well as diminished procollagen reporter expression in mutant fish. Analysis of giantin knockout cells expressing a GFP-tagged procollagen showed that procollagen trafficking is independent of giantin. However, our data show that intracellular N-propeptide processing of pro-α1(I) is defective in the absence of giantin. These data demonstrate a conserved role for giantin in collagen biosynthesis and extracellular matrix assembly. Our work also provides evidence of a giantin-dependent pathway for intracellular procollagen processing." @default.
- W3026108885 created "2020-05-29" @default.
- W3026108885 creator A5004412496 @default.
- W3026108885 creator A5026062950 @default.
- W3026108885 creator A5056317148 @default.
- W3026108885 creator A5070464541 @default.
- W3026108885 date "2020-05-26" @default.
- W3026108885 modified "2023-09-27" @default.
- W3026108885 title "Giantin is required for intracellular N-terminal processing of type I procollagen" @default.
- W3026108885 cites W1499047562 @default.
- W3026108885 cites W1533292277 @default.
- W3026108885 cites W1537357626 @default.
- W3026108885 cites W1577997208 @default.
- W3026108885 cites W1641205561 @default.
- W3026108885 cites W1665676317 @default.
- W3026108885 cites W1965030844 @default.
- W3026108885 cites W1973260880 @default.
- W3026108885 cites W1980916535 @default.
- W3026108885 cites W1983256487 @default.
- W3026108885 cites W1984254664 @default.
- W3026108885 cites W1985760676 @default.
- W3026108885 cites W2005878155 @default.
- W3026108885 cites W2010378383 @default.
- W3026108885 cites W2010746038 @default.
- W3026108885 cites W2015663961 @default.
- W3026108885 cites W2018549462 @default.
- W3026108885 cites W2027343166 @default.
- W3026108885 cites W2029053704 @default.
- W3026108885 cites W2029212512 @default.
- W3026108885 cites W2031211461 @default.
- W3026108885 cites W2033705265 @default.
- W3026108885 cites W2035283321 @default.
- W3026108885 cites W2043324515 @default.
- W3026108885 cites W2047524138 @default.
- W3026108885 cites W2049050052 @default.
- W3026108885 cites W2049247159 @default.
- W3026108885 cites W2059470587 @default.
- W3026108885 cites W2061447135 @default.
- W3026108885 cites W2068229249 @default.
- W3026108885 cites W2077703010 @default.
- W3026108885 cites W2077925923 @default.
- W3026108885 cites W2081172215 @default.
- W3026108885 cites W2081451191 @default.
- W3026108885 cites W2082924324 @default.
- W3026108885 cites W2084285608 @default.
- W3026108885 cites W2091557240 @default.
- W3026108885 cites W2104813756 @default.
- W3026108885 cites W2116169917 @default.
- W3026108885 cites W2124492445 @default.
- W3026108885 cites W2133917860 @default.
- W3026108885 cites W2134666212 @default.
- W3026108885 cites W2148743985 @default.
- W3026108885 cites W2154643336 @default.
- W3026108885 cites W2166391822 @default.
- W3026108885 cites W2166815562 @default.
- W3026108885 cites W2167279371 @default.
- W3026108885 cites W2168388371 @default.
- W3026108885 cites W2169127853 @default.
- W3026108885 cites W2169286218 @default.
- W3026108885 cites W2292924776 @default.
- W3026108885 cites W2399638176 @default.
- W3026108885 cites W2766136641 @default.
- W3026108885 cites W2794718535 @default.
- W3026108885 cites W2914796915 @default.
- W3026108885 cites W2949230683 @default.
- W3026108885 cites W2950723153 @default.
- W3026108885 cites W2964442597 @default.
- W3026108885 cites W2965518123 @default.
- W3026108885 cites W2972662355 @default.
- W3026108885 cites W2997762805 @default.
- W3026108885 cites W4233700458 @default.
- W3026108885 cites W4254461284 @default.
- W3026108885 cites W66128515 @default.
- W3026108885 doi "https://doi.org/10.1101/2020.05.25.115279" @default.
- W3026108885 hasPublicationYear "2020" @default.
- W3026108885 type Work @default.
- W3026108885 sameAs 3026108885 @default.
- W3026108885 citedByCount "2" @default.
- W3026108885 countsByYear W30261088852021 @default.
- W3026108885 countsByYear W30261088852023 @default.
- W3026108885 crossrefType "posted-content" @default.
- W3026108885 hasAuthorship W3026108885A5004412496 @default.
- W3026108885 hasAuthorship W3026108885A5026062950 @default.
- W3026108885 hasAuthorship W3026108885A5056317148 @default.
- W3026108885 hasAuthorship W3026108885A5070464541 @default.
- W3026108885 hasBestOaLocation W30261088851 @default.
- W3026108885 hasConcept C104317684 @default.
- W3026108885 hasConcept C143065580 @default.
- W3026108885 hasConcept C153911025 @default.
- W3026108885 hasConcept C185592680 @default.
- W3026108885 hasConcept C189165786 @default.
- W3026108885 hasConcept C2777313579 @default.
- W3026108885 hasConcept C55493867 @default.
- W3026108885 hasConcept C64348721 @default.
- W3026108885 hasConcept C79879829 @default.
- W3026108885 hasConcept C86803240 @default.
- W3026108885 hasConcept C95444343 @default.
- W3026108885 hasConceptScore W3026108885C104317684 @default.
- W3026108885 hasConceptScore W3026108885C143065580 @default.
- W3026108885 hasConceptScore W3026108885C153911025 @default.