FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026134920> ?p ?o ?g. }

• W3026134920 abstract "Alzheimer's disease (AD) is a progressive neurodegenerative disease. It can lead to progressive cognitive impairment, memory loss, and behavioral alterations. So far, the exact cellular and molecular mechanisms underlying this disorder remain unclear. And there are no effective treatments to prevent, halt, or reverse AD. In recent years, Chinese traditional medicine has become a new force in the treatment of AD, and the typical representatives of natural herbal ingredients are curcumin and its derivatives. Bisdemethoxycurcumin (BDMC), which is a classical derivative of curcumin, was found to have neuroprotective effects against a cell model of Alzheimer's disease (AD) in our previous studies. This study investigated the intrinsic mechanism of BDMC against AD in animal models.In this study, BDMC was injected into the lateral ventricles of normal C57BL/6 mice, APP/PS mice, and APP/PS mice treated with EX527 (the inhibitor of SIRT1). Y maze and Morris water maze were used to test the learning and memory ability of mice. Nissl staining was used to observe the morphological changes of neurons. Immunofluorescence staining was used to detect Aβ deposition in mice. The activities of GSH and SOD were determined to observe the levels of oxidative stress in mice. And Western blot analyses were used to detect content of SIRT1 in mice.In the APP/PS mice, after BDMC intervention, their cognitive function improved, oxidative stress adjusted, the number of neurons increased, Aβ deposition decreased, and the level of SIRT1 expression increased. However, when SIRT1 is inhibited, BDMC on the improvement in the learning and memory ability and the improvement on oxidative stress in APP/PS1 mice were reversed.Our findings demonstrated that in the AD mice, BDMC has antagonistic effect on AD. And an intermediate step in the antagonism effect is caused by SIRT1 upregulation, which leading to decreased oxidative stress. Based on these, we concluded that BDMC injection into the lateral ventricle can act against AD by upregulating SIRT1 to antioxidative stress." @default.
• W3026134920 created "2020-05-29" @default.
• W3026134920 creator A5001768320 @default.
• W3026134920 creator A5006897054 @default.
• W3026134920 creator A5025612495 @default.
• W3026134920 creator A5027459729 @default.
• W3026134920 creator A5028837344 @default.
• W3026134920 creator A5044734672 @default.
• W3026134920 creator A5045974754 @default.
• W3026134920 creator A5056345834 @default.
• W3026134920 creator A5056611624 @default.
• W3026134920 creator A5068902758 @default.
• W3026134920 creator A5082449761 @default.
• W3026134920 creator A5082549798 @default.
• W3026134920 creator A5083453098 @default.
• W3026134920 date "2020-05-22" @default.
• W3026134920 modified "2023-10-14" @default.
• W3026134920 title "Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up‐regulating SIRT1" @default.
• W3026134920 cites W1754499041 @default.
• W3026134920 cites W1804923980 @default.
• W3026134920 cites W1926960484 @default.
• W3026134920 cites W1969441221 @default.
• W3026134920 cites W1974383833 @default.
• W3026134920 cites W1983728938 @default.
• W3026134920 cites W1993534837 @default.
• W3026134920 cites W1994580609 @default.
• W3026134920 cites W2002181764 @default.
• W3026134920 cites W2036090034 @default.
• W3026134920 cites W2044627978 @default.
• W3026134920 cites W2064207652 @default.
• W3026134920 cites W2067108324 @default.
• W3026134920 cites W2068821865 @default.
• W3026134920 cites W2079105065 @default.
• W3026134920 cites W2080274663 @default.
• W3026134920 cites W2087330696 @default.
• W3026134920 cites W2090995263 @default.
• W3026134920 cites W2159879659 @default.
• W3026134920 cites W2166977775 @default.
• W3026134920 cites W2251672701 @default.
• W3026134920 cites W2300267317 @default.
• W3026134920 cites W2328748503 @default.
• W3026134920 cites W2469512664 @default.
• W3026134920 cites W2528587976 @default.
• W3026134920 cites W2558209914 @default.
• W3026134920 cites W2610817715 @default.
• W3026134920 cites W2752059618 @default.
• W3026134920 cites W2913744042 @default.
• W3026134920 cites W2984507335 @default.
• W3026134920 cites W2993309042 @default.
• W3026134920 cites W2999617589 @default.
• W3026134920 cites W3000945988 @default.
• W3026134920 cites W3006572353 @default.
• W3026134920 cites W3026134920 @default.
• W3026134920 doi "https://doi.org/10.1002/brb3.1655" @default.
• W3026134920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7375129" @default.
• W3026134920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32441492" @default.
• W3026134920 hasPublicationYear "2020" @default.
• W3026134920 type Work @default.
• W3026134920 sameAs 3026134920 @default.
• W3026134920 citedByCount "26" @default.
• W3026134920 countsByYear W30261349202020 @default.
• W3026134920 countsByYear W30261349202021 @default.
• W3026134920 countsByYear W30261349202022 @default.
• W3026134920 countsByYear W30261349202023 @default.
• W3026134920 crossrefType "journal-article" @default.
• W3026134920 hasAuthorship W3026134920A5001768320 @default.
• W3026134920 hasAuthorship W3026134920A5006897054 @default.
• W3026134920 hasAuthorship W3026134920A5025612495 @default.
• W3026134920 hasAuthorship W3026134920A5027459729 @default.
• W3026134920 hasAuthorship W3026134920A5028837344 @default.
• W3026134920 hasAuthorship W3026134920A5044734672 @default.
• W3026134920 hasAuthorship W3026134920A5045974754 @default.
• W3026134920 hasAuthorship W3026134920A5056345834 @default.
• W3026134920 hasAuthorship W3026134920A5056611624 @default.
• W3026134920 hasAuthorship W3026134920A5068902758 @default.
• W3026134920 hasAuthorship W3026134920A5082449761 @default.
• W3026134920 hasAuthorship W3026134920A5082549798 @default.
• W3026134920 hasAuthorship W3026134920A5083453098 @default.
• W3026134920 hasBestOaLocation W30261349201 @default.
• W3026134920 hasConcept C104317684 @default.
• W3026134920 hasConcept C134018914 @default.
• W3026134920 hasConcept C142724271 @default.
• W3026134920 hasConcept C169760540 @default.
• W3026134920 hasConcept C185592680 @default.
• W3026134920 hasConcept C25498285 @default.
• W3026134920 hasConcept C2776151105 @default.
• W3026134920 hasConcept C2776415932 @default.
• W3026134920 hasConcept C2778250585 @default.
• W3026134920 hasConcept C2781161787 @default.
• W3026134920 hasConcept C37753355 @default.
• W3026134920 hasConcept C44752575 @default.
• W3026134920 hasConcept C55493867 @default.
• W3026134920 hasConcept C71924100 @default.
• W3026134920 hasConcept C74864618 @default.
• W3026134920 hasConcept C86803240 @default.
• W3026134920 hasConcept C98274493 @default.
• W3026134920 hasConceptScore W3026134920C104317684 @default.
• W3026134920 hasConceptScore W3026134920C134018914 @default.
• W3026134920 hasConceptScore W3026134920C142724271 @default.
• W3026134920 hasConceptScore W3026134920C169760540 @default.

• next