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• W3026202285 endingPage "6135" @default.
• W3026202285 startingPage "6122" @default.
• W3026202285 abstract "EGFR TKI therapy has become a first-line regimen for non-small cell lung cancer (NSCLC) patients with EGRF mutations. However, there are two big challenges against effective therapy--the secondary EGFR mutation-associated TKI resistance and brain metastasis (BMs) of lung cancer. The BMs is a major cause of death for advanced NSCLC patients, and the treatment of BMs with TKI resistance remains difficult. Methods: Tumor-associated macrophages (TAM) is a promising drug target for inhibiting tumor growth, overcoming drug resistance, and anti-metastasis. TAM also plays an essential role in regulating tumor microenvironment. We developed a dual-targeting liposomal system with modification of anti-PD-L1 nanobody and transferrin receptor (TfR)-binding peptide T12 for codelivery of simvastatin/gefitinib to treat BMs of NSCLC. Results: The dual-targeting liposomes could efficiently penetrate the blood-brain barrier (BBB) and enter the BMs, acting on TAM repolarization and reversal of EGFRT790M-associated drug resistance. The treatment mechanisms were related to the elevating ROS and the suppression of the EGFR/Akt/Erk signaling pathway. Conclusion: The dual-targeting liposomal codelivery system offers a promising strategy for treating the advanced EGFRT790M NSCLC patients with BMs." @default.
• W3026202285 created "2020-05-29" @default.
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• W3026202285 date "2020-01-01" @default.
• W3026202285 modified "2023-10-16" @default.
• W3026202285 title "BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFR^T790M mutation" @default.
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• W3026202285 doi "https://doi.org/10.7150/thno.42234" @default.
• W3026202285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7255027" @default.
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• W3026202285 hasPublicationYear "2020" @default.
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