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• W3026223721 endingPage "3584" @default.
• W3026223721 startingPage "3584" @default.
• W3026223721 abstract "Coiled-coils, the bundles of intertwined helical protein motifs, have drawn much attention as versatile molecular toolkits. Because of programmable interaction specificity and affinity as well as well-established sequence-to-structure relationships, coiled-coils have been used as subunits that self-assemble various molecular complexes in a range of fields. In this review, I describe recent advances in the field of protein nanotechnology, with a focus on programming assembly of protein nanostructures using coiled-coil modules. Modular design approaches to converting the helical motifs into self-assembling building blocks are described, followed by a discussion on the molecular basis and principles underlying the modular designs. This review also provides a summary of recently developed nanostructures with a variety of structural features, which are in categories of unbounded nanostructures, discrete nanoparticles, and well-defined origami nanostructures. Challenges existing in current design strategies, as well as desired improvements for controls over material properties and functionalities for applications, are also provided." @default.
• W3026223721 created "2020-05-29" @default.
• W3026223721 creator A5030940683 @default.
• W3026223721 date "2020-05-19" @default.
• W3026223721 modified "2023-10-05" @default.
• W3026223721 title "Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures" @default.
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• W3026223721 doi "https://doi.org/10.3390/ijms21103584" @default.
• W3026223721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7278914" @default.
• W3026223721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32438665" @default.
• W3026223721 hasPublicationYear "2020" @default.
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