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- W3026290999 abstract "Abstract The control of cysteine reactivity is of paramount importance for the synthesis of proteins using the native chemical ligation (NCL) reaction. We report that this goal can be achieved in a traceless manner during ligation by appending a simple N -selenoethyl group to cysteine. While in synthetic organic chemistry the cleavage of carbon-nitrogen bonds is notoriously difficult, we describe that N -selenoethyl cysteine (SetCys) loses its selenoethyl arm in water under mild conditions upon reduction of its selenosulfide bond. Detailed mechanistic investigations show that the cleavage of the selenoethyl arm proceeds through an anionic mechanism with assistance of the cysteine thiol group. The implementation of the SetCys unit in a process enabling the modular and straightforward assembly of linear or backbone cyclized polypeptides is illustrated by the synthesis of biologically active cyclic hepatocyte growth factor variants." @default.
- W3026290999 created "2020-05-29" @default.
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- W3026290999 date "2020-05-22" @default.
- W3026290999 modified "2023-10-14" @default.
- W3026290999 title "A cysteine selenosulfide redox switch for protein chemical synthesis" @default.
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- W3026290999 doi "https://doi.org/10.1038/s41467-020-16359-6" @default.
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