Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026308265> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3026308265 endingPage "290" @default.
- W3026308265 startingPage "271" @default.
- W3026308265 abstract "Benzodiazepines administration produces amnesic and anxiolytic effects. The non-benzodiazepine anxiolytics, like buspirone (BU), seems to have low amnesic effects, but the results obtained vary with the procedures used to evaluate these effects. The elevated T-maze (ETM) is a procedure that allows evaluating both, the amnesic and anxiolytic effects. In the present study, we examined the effect of the administration of a cholinergic antagonist, scopolamine (SC), a classical amnesic agent, and two anxiolytics, diazepam (DZ) and BU in the ETM. Male Wistar rats (200-250 g) were tested in the ETM during 5 min after one of the following treatments: SC (0.5, 1, 3 mg/kg, DZ (2, 5 mg/kg), BU (2, 5 mg/kg) or saline (SAL). In training day each subject was injected and placed in the enclosed arm and the time remaining in this arm was registered; two subsequent avoidance trials (AV) were given. After avoidance trials, each subject was placed in the open arm and the latency to escape (ES) was recorded. In the retention test, the AV and ES latencies were recorded 24 hr after without the administration of the drug. Significant impairment was observed for avoidance latencies in acquisition and retention in the SC groups compared with saline; no changes were observed for escape latencies. Similar effects but in a lesser extent were observed for diazepam in acquisition and retention avoidance latencies; an increase in escape latencies was observed suggesting an anxiolytic effect. Buspirone had no effect in acquisition and retention avoidance latencies; in the animals treated with the higher dose of BU an increase in escape latencies was observed in the first day suggesting an anxiolytic effect. Present results suggest that SC has amnesic effects, but no anxiolytics, DZ and BU induced an anxiolytic effect, but only diazepam induced anterograde amnesia, and that these effects could be dissociated using the ETM." @default.
- W3026308265 created "2020-05-29" @default.
- W3026308265 creator A5037014314 @default.
- W3026308265 creator A5054554544 @default.
- W3026308265 creator A5057629071 @default.
- W3026308265 creator A5066203769 @default.
- W3026308265 creator A5085256444 @default.
- W3026308265 date "2011-01-24" @default.
- W3026308265 modified "2023-09-26" @default.
- W3026308265 title "Dissociation of anxiolytic and amnesic effects in the elevated T-maze" @default.
- W3026308265 hasPublicationYear "2011" @default.
- W3026308265 type Work @default.
- W3026308265 sameAs 3026308265 @default.
- W3026308265 citedByCount "0" @default.
- W3026308265 crossrefType "journal-article" @default.
- W3026308265 hasAuthorship W3026308265A5037014314 @default.
- W3026308265 hasAuthorship W3026308265A5054554544 @default.
- W3026308265 hasAuthorship W3026308265A5057629071 @default.
- W3026308265 hasAuthorship W3026308265A5066203769 @default.
- W3026308265 hasAuthorship W3026308265A5085256444 @default.
- W3026308265 hasConcept C118552586 @default.
- W3026308265 hasConcept C126322002 @default.
- W3026308265 hasConcept C15744967 @default.
- W3026308265 hasConcept C170493617 @default.
- W3026308265 hasConcept C173586616 @default.
- W3026308265 hasConcept C2775864247 @default.
- W3026308265 hasConcept C2776175493 @default.
- W3026308265 hasConcept C2777287423 @default.
- W3026308265 hasConcept C2777397205 @default.
- W3026308265 hasConcept C2777765862 @default.
- W3026308265 hasConcept C2778173252 @default.
- W3026308265 hasConcept C42219234 @default.
- W3026308265 hasConcept C558461103 @default.
- W3026308265 hasConcept C71924100 @default.
- W3026308265 hasConcept C98274493 @default.
- W3026308265 hasConceptScore W3026308265C118552586 @default.
- W3026308265 hasConceptScore W3026308265C126322002 @default.
- W3026308265 hasConceptScore W3026308265C15744967 @default.
- W3026308265 hasConceptScore W3026308265C170493617 @default.
- W3026308265 hasConceptScore W3026308265C173586616 @default.
- W3026308265 hasConceptScore W3026308265C2775864247 @default.
- W3026308265 hasConceptScore W3026308265C2776175493 @default.
- W3026308265 hasConceptScore W3026308265C2777287423 @default.
- W3026308265 hasConceptScore W3026308265C2777397205 @default.
- W3026308265 hasConceptScore W3026308265C2777765862 @default.
- W3026308265 hasConceptScore W3026308265C2778173252 @default.
- W3026308265 hasConceptScore W3026308265C42219234 @default.
- W3026308265 hasConceptScore W3026308265C558461103 @default.
- W3026308265 hasConceptScore W3026308265C71924100 @default.
- W3026308265 hasConceptScore W3026308265C98274493 @default.
- W3026308265 hasIssue "2" @default.
- W3026308265 hasLocation W30263082651 @default.
- W3026308265 hasOpenAccess W3026308265 @default.
- W3026308265 hasPrimaryLocation W30263082651 @default.
- W3026308265 hasRelatedWork W133267589 @default.
- W3026308265 hasRelatedWork W187471250 @default.
- W3026308265 hasRelatedWork W1969750257 @default.
- W3026308265 hasRelatedWork W1989710177 @default.
- W3026308265 hasRelatedWork W1999209780 @default.
- W3026308265 hasRelatedWork W2057306819 @default.
- W3026308265 hasRelatedWork W2066148220 @default.
- W3026308265 hasRelatedWork W2070545051 @default.
- W3026308265 hasRelatedWork W2083322296 @default.
- W3026308265 hasRelatedWork W2137510615 @default.
- W3026308265 hasRelatedWork W2182718235 @default.
- W3026308265 hasRelatedWork W2195407138 @default.
- W3026308265 hasRelatedWork W2268811623 @default.
- W3026308265 hasRelatedWork W2331261837 @default.
- W3026308265 hasRelatedWork W2357921021 @default.
- W3026308265 hasRelatedWork W2405946333 @default.
- W3026308265 hasRelatedWork W2442826463 @default.
- W3026308265 hasRelatedWork W2520127190 @default.
- W3026308265 hasRelatedWork W812116446 @default.
- W3026308265 hasRelatedWork W2525214545 @default.
- W3026308265 hasVolume "32" @default.
- W3026308265 isParatext "false" @default.
- W3026308265 isRetracted "false" @default.
- W3026308265 magId "3026308265" @default.
- W3026308265 workType "article" @default.