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- W3026322128 abstract "Abstract Lead (Pb) is a heavy metal toxic to the immune system, yet the influence of Pb on innate lymphoid cells (ILC) remains to be defined. In this study, we found that occupationally relevant level of Pb exposure impaired ILC development at the progenitor level by activating Janus Kinase1. C57BL/6 mice treated with 1250 ppm, but not 125 ppm Pb acetic via drinking water for 8 weeks had reduced number of mature ILC, which was not caused by increased apoptosis or suppressed proliferation. Conversely, Pb increased the number of innate lymphoid cell progenitors (ILCP) in the bone marrow. The discordant observation indicated that an obstruction of ILCP differentiation into mature ILC during Pb exposure existed. Pb directly acted on ILCP to suppress their proliferation, indicating that ILCP were less activated during Pb exposure. Reciprocal ILCP transplantation assay confirmed that Pb impeded the differentiation of ILCP into mature ILC, as ILCP gave rise to fewer mature ILC in Pb-treated recipients compared with control recipients. In vitro assays suggested that the obstruction of ILCP differentiation by Pb exposure was due to increased activation of Janus Kinase1. Thus, Pb impeded ILCP differentiation into mature ILC to result in an accumulation of ILCP in the bone marrow and the resultant decreased number of mature ILC in lymphoid and nonlymphoid tissues in mice. Moreover, by analyses of ILC and ILCP in peripheral blood mononuclear cells of human subjects occupationally exposed to Pb, we revealed that Pb might also impede the development of ILC in human." @default.
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- W3026322128 date "2020-05-19" @default.
- W3026322128 modified "2023-10-12" @default.
- W3026322128 title "Lead Impairs the Development of Innate Lymphoid Cells by Impeding the Differentiation of Their Progenitors" @default.
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- W3026322128 cites W1978311073 @default.
- W3026322128 cites W1983476428 @default.
- W3026322128 cites W2002307060 @default.
- W3026322128 cites W2012071302 @default.
- W3026322128 cites W2033289727 @default.
- W3026322128 cites W2037482308 @default.
- W3026322128 cites W2047882259 @default.
- W3026322128 cites W2072411272 @default.
- W3026322128 cites W2075150851 @default.
- W3026322128 cites W2076298841 @default.
- W3026322128 cites W2097169249 @default.
- W3026322128 cites W2100065945 @default.
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- W3026322128 cites W2129892121 @default.
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- W3026322128 cites W2163479668 @default.
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- W3026322128 cites W2323325951 @default.
- W3026322128 cites W2333387353 @default.
- W3026322128 cites W2345615811 @default.
- W3026322128 cites W2466489636 @default.
- W3026322128 cites W2471110308 @default.
- W3026322128 cites W2474204846 @default.
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- W3026322128 cites W2603210259 @default.
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- W3026322128 cites W2620907542 @default.
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- W3026322128 cites W2782187941 @default.
- W3026322128 cites W2789368077 @default.
- W3026322128 cites W2791568145 @default.
- W3026322128 cites W2792405992 @default.
- W3026322128 cites W2792915309 @default.
- W3026322128 cites W2806016149 @default.
- W3026322128 cites W2810901833 @default.
- W3026322128 cites W2885895269 @default.
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- W3026322128 doi "https://doi.org/10.1093/toxsci/kfaa074" @default.
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