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- W3026376212 abstract "Functional dyes are useful tool in Biomedical and Life Sciences. In chapter 2 and 3, we introduced a general and simple design concept using unnatural amino acids (UAAs) as flexible scaffold to link organic fluorophore covalently to a photostabilizer on an arbitrary biomolecular target using only NHS- or click chemistry. With this method, chemically distinct fluorophore species that could not be studied before can be improved through intramolecular photostabilization as “self-healing” fluorophores. . In chapter 4, we developed novel photoswitchable aminoglycosides, that we can call “Opto-Drugs”, which can resist aminoglycoside-modifying enzymes while simultaneously demonstrating selective antibiotic activities upon visible light light irradiation. In chapter 5, we generate an artificial photoresponsive system based on genetically encoded aptameric RNA that can respond to photoisomerizable, cell-permeable small molecules." @default.
- W3026376212 created "2020-05-29" @default.
- W3026376212 creator A5077703699 @default.
- W3026376212 date "2020-06-04" @default.
- W3026376212 modified "2023-09-23" @default.
- W3026376212 title "Applications of functional dyes in biomedicine and life sciences" @default.
- W3026376212 doi "https://doi.org/10.33612/diss.123828369" @default.
- W3026376212 hasPublicationYear "2020" @default.
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