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- W3026420678 abstract "Abstract Objective Estimate the time-course of the spread of key pathological markers and the onset of cognitive dysfunction in Alzheimer’s disease. Methods In a cohort of 336 older adults, ranging in cognitive functioning, we estimated the time of initial changes of Aβ, tau, and decreases in cognition with respect to the time of Aβ-positivity. Results Small effect sizes of change in CSF Aβ42 and regional Aβ PET were estimated to occur several decades before Aβ-positivity. Increases in CSF tau occurred 11-12 years before Aβ-positivity. Temporoparietal tau PET showed increases 4-5 years before Aβ-positivity. Subtle cognitive dysfunction was observed 7-9 years before Aβ-positivity. Conclusions Increases in tau and cognitive dysfunction occur years before the presence of significant Aβ. Explicit estimates of the time for these events provide a clearer picture of the time course of the amyloid cascade and identify potential windows for specific treatments." @default.
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- W3026420678 date "2020-05-21" @default.
- W3026420678 modified "2023-09-27" @default.
- W3026420678 title "Time between milestone events in the Alzheimer’s disease amyloid cascade" @default.
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- W3026420678 doi "https://doi.org/10.1101/2020.05.18.103226" @default.
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