FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026456411> ?p ?o ?g. }

• W3026456411 endingPage "1152" @default.
• W3026456411 startingPage "1145" @default.
• W3026456411 abstract "Prazosin, an α-adrenergic receptor antagonist, is used to treat mild to moderate hypertension. It has recently been discovered that α‑adrenergic receptors may have potential antitumor properties. Therefore, in the present study, the effect of prazosin on human glioblastoma and the underlying mechanism were investigated. Human glioblastoma U251 and U87 cells were treated with different concentrations of prazosin, and a Cell Counting Kit‑8 assay was performed to investigate the effects of prazosin on cell proliferation. Transwell migration and invasion assays were used to assess the effects of prazosin on cell migration and invasion. Prazosin‑induced apoptosis in U251 and U87 cells was detected by flow cytometry, and the protein expression levels of anti‑apoptotic proteins and proteins related to the PI3K/AKT/mTOR signaling pathway were detected by western blotting. The results suggested that following treatment with prazosin, the proliferation, migration and invasion of U251 and U81 cells were decreased. By contrast, U251 and U81 cell apoptosis, as well as the protein expression levels of Bax and active Caspase‑3 were increased after prazosin treatment (P<0.05). Bcl‑2 levels were also decreased after prazosin treatment (P<0.05). Additionally, the expression of phosphorylated (p)‑AKT and p‑mTOR, P70 and cyclin D1 were decreased in U251 and U81 cells following prazosin treatment (P<0.05). The present study suggested that prazosin may suppress glioblastoma progression by downregulating the activity of the PI3K/AKT/mTOR signaling pathway." @default.
• W3026456411 created "2020-05-29" @default.
• W3026456411 creator A5029634246 @default.
• W3026456411 creator A5062617254 @default.
• W3026456411 date "2020-05-19" @default.
• W3026456411 modified "2023-09-30" @default.
• W3026456411 title "Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway" @default.
• W3026456411 cites W11687661 @default.
• W3026456411 cites W1486952607 @default.
• W3026456411 cites W1498865094 @default.
• W3026456411 cites W1640337403 @default.
• W3026456411 cites W1881666557 @default.
• W3026456411 cites W1965156778 @default.
• W3026456411 cites W1975137665 @default.
• W3026456411 cites W1983733795 @default.
• W3026456411 cites W1984941270 @default.
• W3026456411 cites W2001102844 @default.
• W3026456411 cites W2026506846 @default.
• W3026456411 cites W2030072142 @default.
• W3026456411 cites W2030250579 @default.
• W3026456411 cites W2037911414 @default.
• W3026456411 cites W2038629933 @default.
• W3026456411 cites W2041328797 @default.
• W3026456411 cites W2068229930 @default.
• W3026456411 cites W2071274705 @default.
• W3026456411 cites W2080100938 @default.
• W3026456411 cites W2081433330 @default.
• W3026456411 cites W2087448478 @default.
• W3026456411 cites W2095151261 @default.
• W3026456411 cites W2096287682 @default.
• W3026456411 cites W2107436171 @default.
• W3026456411 cites W2122698051 @default.
• W3026456411 cites W2129425749 @default.
• W3026456411 cites W2138951875 @default.
• W3026456411 cites W2145006924 @default.
• W3026456411 cites W2149514290 @default.
• W3026456411 cites W2152172559 @default.
• W3026456411 cites W2155162254 @default.
• W3026456411 cites W2160487921 @default.
• W3026456411 cites W2164043594 @default.
• W3026456411 cites W2184371508 @default.
• W3026456411 cites W2185052166 @default.
• W3026456411 cites W2315027863 @default.
• W3026456411 cites W2316732799 @default.
• W3026456411 cites W2340752487 @default.
• W3026456411 cites W2409740971 @default.
• W3026456411 cites W2526011086 @default.
• W3026456411 cites W2586121379 @default.
• W3026456411 cites W2744650340 @default.
• W3026456411 cites W2779801289 @default.
• W3026456411 cites W2946025210 @default.
• W3026456411 cites W73486977 @default.
• W3026456411 doi "https://doi.org/10.3892/etm.2020.8772" @default.
• W3026456411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7388556" @default.
• W3026456411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32765662" @default.
• W3026456411 hasPublicationYear "2020" @default.
• W3026456411 type Work @default.
• W3026456411 sameAs 3026456411 @default.
• W3026456411 citedByCount "6" @default.
• W3026456411 countsByYear W30264564112022 @default.
• W3026456411 countsByYear W30264564112023 @default.
• W3026456411 crossrefType "journal-article" @default.
• W3026456411 hasAuthorship W3026456411A5029634246 @default.
• W3026456411 hasAuthorship W3026456411A5062617254 @default.
• W3026456411 hasBestOaLocation W30264564111 @default.
• W3026456411 hasConcept C137738243 @default.
• W3026456411 hasConcept C1491633281 @default.
• W3026456411 hasConcept C170493617 @default.
• W3026456411 hasConcept C185592680 @default.
• W3026456411 hasConcept C190283241 @default.
• W3026456411 hasConcept C2776885963 @default.
• W3026456411 hasConcept C2780648677 @default.
• W3026456411 hasConcept C29537977 @default.
• W3026456411 hasConcept C502942594 @default.
• W3026456411 hasConcept C55493867 @default.
• W3026456411 hasConcept C62112901 @default.
• W3026456411 hasConcept C62478195 @default.
• W3026456411 hasConcept C75217442 @default.
• W3026456411 hasConcept C86554907 @default.
• W3026456411 hasConcept C86803240 @default.
• W3026456411 hasConcept C95444343 @default.
• W3026456411 hasConceptScore W3026456411C137738243 @default.
• W3026456411 hasConceptScore W3026456411C1491633281 @default.
• W3026456411 hasConceptScore W3026456411C170493617 @default.
• W3026456411 hasConceptScore W3026456411C185592680 @default.
• W3026456411 hasConceptScore W3026456411C190283241 @default.
• W3026456411 hasConceptScore W3026456411C2776885963 @default.
• W3026456411 hasConceptScore W3026456411C2780648677 @default.
• W3026456411 hasConceptScore W3026456411C29537977 @default.
• W3026456411 hasConceptScore W3026456411C502942594 @default.
• W3026456411 hasConceptScore W3026456411C55493867 @default.
• W3026456411 hasConceptScore W3026456411C62112901 @default.
• W3026456411 hasConceptScore W3026456411C62478195 @default.
• W3026456411 hasConceptScore W3026456411C75217442 @default.
• W3026456411 hasConceptScore W3026456411C86554907 @default.
• W3026456411 hasConceptScore W3026456411C86803240 @default.
• W3026456411 hasConceptScore W3026456411C95444343 @default.
• W3026456411 hasIssue "2" @default.

• next