Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026478637> ?p ?o ?g. }
- W3026478637 endingPage "247054702092484" @default.
- W3026478637 startingPage "247054702092484" @default.
- W3026478637 abstract "Genome-wide association studies (GWAS) have been performed for many psychiatric disorders and revealed a complex polygenic architecture linking mental and physical health phenotypes. Psychiatric diagnoses are often heterogeneous, and several layers of trait heterogeneity may contribute to detection of genetic risks per disorder or across multiple disorders. In this review, we discuss these heterogeneities and their consequences on the discovery of risk loci using large-scale genetic data. We primarily highlight the ways in which sex and diagnostic complexity contribute to risk locus discovery in schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, posttraumatic stress disorder, major depressive disorder, obsessive-compulsive disorder, Tourette’s syndrome and chronic tic disorder, anxiety disorders, suicidality, feeding and eating disorders, and substance use disorders. Genetic data also have facilitated discovery of clinically relevant subphenotypes also described here. Collectively, GWAS of psychiatric disorders revealed that the understanding of heterogeneity, polygenicity, and pleiotropy is critical to translate genetic findings into treatment strategies." @default.
- W3026478637 created "2020-05-29" @default.
- W3026478637 creator A5015278880 @default.
- W3026478637 creator A5020097225 @default.
- W3026478637 creator A5046428769 @default.
- W3026478637 creator A5053756905 @default.
- W3026478637 creator A5088147704 @default.
- W3026478637 date "2020-01-01" @default.
- W3026478637 modified "2023-10-10" @default.
- W3026478637 title "Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective" @default.
- W3026478637 cites W1511374377 @default.
- W3026478637 cites W1639640383 @default.
- W3026478637 cites W1731053727 @default.
- W3026478637 cites W1909324251 @default.
- W3026478637 cites W1964286403 @default.
- W3026478637 cites W1968016966 @default.
- W3026478637 cites W1969616719 @default.
- W3026478637 cites W1978724939 @default.
- W3026478637 cites W1981277671 @default.
- W3026478637 cites W1984246108 @default.
- W3026478637 cites W1985730575 @default.
- W3026478637 cites W1987911043 @default.
- W3026478637 cites W1987925623 @default.
- W3026478637 cites W1991873507 @default.
- W3026478637 cites W1993663642 @default.
- W3026478637 cites W1997057722 @default.
- W3026478637 cites W1997963263 @default.
- W3026478637 cites W1999655867 @default.
- W3026478637 cites W2000594564 @default.
- W3026478637 cites W2001183909 @default.
- W3026478637 cites W2008269838 @default.
- W3026478637 cites W2009980098 @default.
- W3026478637 cites W2011741757 @default.
- W3026478637 cites W2017867103 @default.
- W3026478637 cites W2019763316 @default.
- W3026478637 cites W2022786386 @default.
- W3026478637 cites W2028758511 @default.
- W3026478637 cites W2030528466 @default.
- W3026478637 cites W2033648797 @default.
- W3026478637 cites W2047640349 @default.
- W3026478637 cites W2050414031 @default.
- W3026478637 cites W2051719689 @default.
- W3026478637 cites W2065692954 @default.
- W3026478637 cites W2088913489 @default.
- W3026478637 cites W2090000904 @default.
- W3026478637 cites W2093956584 @default.
- W3026478637 cites W2094287065 @default.
- W3026478637 cites W2096389883 @default.
- W3026478637 cites W2098380904 @default.
- W3026478637 cites W2099969796 @default.
- W3026478637 cites W2101357408 @default.
- W3026478637 cites W2102388069 @default.
- W3026478637 cites W2105043569 @default.
- W3026478637 cites W2111699978 @default.
- W3026478637 cites W2115598737 @default.
- W3026478637 cites W2116382228 @default.
- W3026478637 cites W2116908385 @default.
- W3026478637 cites W2117062359 @default.
- W3026478637 cites W2121072935 @default.
- W3026478637 cites W2122161847 @default.
- W3026478637 cites W2123649925 @default.
- W3026478637 cites W2129873641 @default.
- W3026478637 cites W2138305418 @default.
- W3026478637 cites W2139326489 @default.
- W3026478637 cites W2140660757 @default.
- W3026478637 cites W2142997789 @default.
- W3026478637 cites W2144626458 @default.
- W3026478637 cites W2153860431 @default.
- W3026478637 cites W2157574219 @default.
- W3026478637 cites W2157941013 @default.
- W3026478637 cites W2160663485 @default.
- W3026478637 cites W2165973903 @default.
- W3026478637 cites W2166059093 @default.
- W3026478637 cites W2168354474 @default.
- W3026478637 cites W2169766342 @default.
- W3026478637 cites W2173304983 @default.
- W3026478637 cites W2179398072 @default.
- W3026478637 cites W2195783463 @default.
- W3026478637 cites W2234251707 @default.
- W3026478637 cites W2236290736 @default.
- W3026478637 cites W2255138985 @default.
- W3026478637 cites W2268628063 @default.
- W3026478637 cites W2282212096 @default.
- W3026478637 cites W2295288073 @default.
- W3026478637 cites W2324316373 @default.
- W3026478637 cites W2325742619 @default.
- W3026478637 cites W2328070697 @default.
- W3026478637 cites W2334909376 @default.
- W3026478637 cites W2338118587 @default.
- W3026478637 cites W2398123200 @default.
- W3026478637 cites W2467603706 @default.
- W3026478637 cites W2492077070 @default.
- W3026478637 cites W2547430741 @default.
- W3026478637 cites W2568419125 @default.
- W3026478637 cites W2569020128 @default.
- W3026478637 cites W2580975499 @default.
- W3026478637 cites W2581245397 @default.
- W3026478637 cites W2586616930 @default.