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- W3026585733 endingPage "476" @default.
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- W3026585733 abstract "Intranasal (IN) drug delivery is recognized to be an innovative strategy to deliver drugs to the Central Nervous System. One of the main limitations of IN dosing is the low volume of drug that can be administered. Accordingly, two requirements are necessary: the drug should be active at a low dosage, and the drug solubility in water must be high enough to accommodate the required dose. Drug nanocrystals may overcome these limitations; thus, curcumin was selected as a model drug to prepare nanocrystals for potential IN administration. With this aim, we designed curcumin nanocrystals (NCs) by using Box Behnken design. A total of 51 formulations were prepared by the sonoprecipitation method. Once we assessed the influence of the independent variables on nanocrystals’ mean diameter, the formulation was optimized based on the desirability function. The optimized formulation was characterized from a physico-chemical point of view to evaluate the mean size, zeta potential, polidispersity index, pH, osmolarity, morphology, thermotropic behavior and the degree of crystallinity. Finally, the cellular uptake of curcumin and curcumin NCs was evaluated on Olfactory Ensheathing Cells (OECs). Our results showed that the OECs efficiently took up the NCs compared to the free curcumin, showing that NCs can ameliorate drug permeability." @default.
- W3026585733 created "2020-05-29" @default.
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- W3026585733 date "2020-05-23" @default.
- W3026585733 modified "2023-10-03" @default.
- W3026585733 title "Optimization of Curcumin Nanocrystals as Promising Strategy for Nose-to-Brain Delivery Application" @default.
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- W3026585733 doi "https://doi.org/10.3390/pharmaceutics12050476" @default.
- W3026585733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7284456" @default.
- W3026585733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32456163" @default.
- W3026585733 hasPublicationYear "2020" @default.
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