FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026602860> ?p ?o ?g. }

• W3026602860 abstract "Abstract We introduce pleiotropic association test (PAT) for joint analysis of multiple traits using GWAS summary statistics. The method utilizes the decomposition of phenotypic covariation into genetic and environmental components to create a likelihood ratio test statistic for each genetic variant. Though PAT does not directly interpret which trait(s) drive the association, a per trait interpretation of the omnibus p-value is provided through an extension to the meta-analysis framework, m-values. In simulations, we show PAT controls the false positive rate, increases statistical power, and is robust to model misspecifications of genetic effect. Additionally, simulations comparing PAT to two multi-trait methods, HIPO and MTAG show PAT having a 43.0% increase in the number of omnibus associations over the other methods. When these associations are interpreted on a per trait level using m-values, PAT has 52.2% more per trait interpretations with a 0.57% false positive assignment rate. When analyzing four traits from the UK Biobank, PAT identifies 22,095 novel associated variants. Through the m-values interpretation framework, the number of total per trait associations for two traits are almost tripled and are nearly doubled for another trait relative to the original single trait GWAS." @default.
• W3026602860 created "2020-05-29" @default.
• W3026602860 creator A5009368988 @default.
• W3026602860 creator A5058484067 @default.
• W3026602860 creator A5076480305 @default.
• W3026602860 date "2020-05-19" @default.
• W3026602860 modified "2023-09-23" @default.
• W3026602860 title "Leveraging pleiotropy in genome-wide association studies in multiple traits with per trait interpretations" @default.
• W3026602860 cites W1981831435 @default.
• W3026602860 cites W2027446786 @default.
• W3026602860 cites W2039153962 @default.
• W3026602860 cites W2041467022 @default.
• W3026602860 cites W2045921606 @default.
• W3026602860 cites W2077646289 @default.
• W3026602860 cites W2083497058 @default.
• W3026602860 cites W2086493366 @default.
• W3026602860 cites W2104549677 @default.
• W3026602860 cites W2139852278 @default.
• W3026602860 cites W2139852368 @default.
• W3026602860 cites W2152603994 @default.
• W3026602860 cites W2153860431 @default.
• W3026602860 cites W2157254929 @default.
• W3026602860 cites W2163184920 @default.
• W3026602860 cites W2195783463 @default.
• W3026602860 cites W2217809488 @default.
• W3026602860 cites W2468727035 @default.
• W3026602860 cites W2503030347 @default.
• W3026602860 cites W2553123256 @default.
• W3026602860 cites W2565199748 @default.
• W3026602860 cites W2767053787 @default.
• W3026602860 cites W2768144164 @default.
• W3026602860 cites W2780560743 @default.
• W3026602860 cites W2806795716 @default.
• W3026602860 cites W2808144139 @default.
• W3026602860 cites W2905138054 @default.
• W3026602860 cites W2948487606 @default.
• W3026602860 cites W2950155437 @default.
• W3026602860 cites W2950863624 @default.
• W3026602860 cites W4249369821 @default.
• W3026602860 doi "https://doi.org/10.1101/2020.05.17.100172" @default.
• W3026602860 hasPublicationYear "2020" @default.
• W3026602860 type Work @default.
• W3026602860 sameAs 3026602860 @default.
• W3026602860 citedByCount "0" @default.
• W3026602860 crossrefType "posted-content" @default.
• W3026602860 hasAuthorship W3026602860A5009368988 @default.
• W3026602860 hasAuthorship W3026602860A5058484067 @default.
• W3026602860 hasAuthorship W3026602860A5076480305 @default.
• W3026602860 hasBestOaLocation W30266028601 @default.
• W3026602860 hasConcept C104317684 @default.
• W3026602860 hasConcept C105795698 @default.
• W3026602860 hasConcept C106208931 @default.
• W3026602860 hasConcept C106934330 @default.
• W3026602860 hasConcept C116567970 @default.
• W3026602860 hasConcept C127716648 @default.
• W3026602860 hasConcept C135763542 @default.
• W3026602860 hasConcept C153209595 @default.
• W3026602860 hasConcept C186413461 @default.
• W3026602860 hasConcept C193244246 @default.
• W3026602860 hasConcept C199360897 @default.
• W3026602860 hasConcept C26207810 @default.
• W3026602860 hasConcept C33923547 @default.
• W3026602860 hasConcept C40696583 @default.
• W3026602860 hasConcept C41008148 @default.
• W3026602860 hasConcept C54355233 @default.
• W3026602860 hasConcept C78458016 @default.
• W3026602860 hasConcept C81941488 @default.
• W3026602860 hasConcept C86803240 @default.
• W3026602860 hasConcept C9287583 @default.
• W3026602860 hasConcept C96608239 @default.
• W3026602860 hasConceptScore W3026602860C104317684 @default.
• W3026602860 hasConceptScore W3026602860C105795698 @default.
• W3026602860 hasConceptScore W3026602860C106208931 @default.
• W3026602860 hasConceptScore W3026602860C106934330 @default.
• W3026602860 hasConceptScore W3026602860C116567970 @default.
• W3026602860 hasConceptScore W3026602860C127716648 @default.
• W3026602860 hasConceptScore W3026602860C135763542 @default.
• W3026602860 hasConceptScore W3026602860C153209595 @default.
• W3026602860 hasConceptScore W3026602860C186413461 @default.
• W3026602860 hasConceptScore W3026602860C193244246 @default.
• W3026602860 hasConceptScore W3026602860C199360897 @default.
• W3026602860 hasConceptScore W3026602860C26207810 @default.
• W3026602860 hasConceptScore W3026602860C33923547 @default.
• W3026602860 hasConceptScore W3026602860C40696583 @default.
• W3026602860 hasConceptScore W3026602860C41008148 @default.
• W3026602860 hasConceptScore W3026602860C54355233 @default.
• W3026602860 hasConceptScore W3026602860C78458016 @default.
• W3026602860 hasConceptScore W3026602860C81941488 @default.
• W3026602860 hasConceptScore W3026602860C86803240 @default.
• W3026602860 hasConceptScore W3026602860C9287583 @default.
• W3026602860 hasConceptScore W3026602860C96608239 @default.
• W3026602860 hasLocation W30266028601 @default.
• W3026602860 hasOpenAccess W3026602860 @default.
• W3026602860 hasPrimaryLocation W30266028601 @default.
• W3026602860 hasRelatedWork W12767799 @default.
• W3026602860 hasRelatedWork W16795009 @default.
• W3026602860 hasRelatedWork W21079765 @default.
• W3026602860 hasRelatedWork W21816734 @default.
• W3026602860 hasRelatedWork W24147420 @default.
• W3026602860 hasRelatedWork W33426044 @default.

• next