Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026616846> ?p ?o ?g. }
- W3026616846 abstract "SUMMARY The human pathogen Legionella pneumophila (L.p.) secretes ~330 bacterial effector proteins into the host cell which interfere with numerous cellular pathways and often regulate host cell proteins through post-translational modifications. However, the cellular targets and functions of most L.p. effectors are not known. In order to obtain a global overview of potential targets of these effectors, we analyzed the host cell proteome, ubiquitinome, and phosphoproteome during L.p. infection. Our analysis reveals dramatic spatiotemporal changes in the host cell proteome that are dependent on the secretion of bacterial effectors. Strikingly, we show that L.p. substantially reshapes the mitochondrial proteome and modulates mitochondrial stress response pathways such as the mitochondrial unfolded protein response (UPR mt ). To our knowledge, this is the first evidence of manipulation of the UPR mt by a bacterial pathogen in mammalian cells. In addition, we have identified a previously uncharacterized L.p. effector that is targeted to host cell mitochondria and protects mitochondrial network integrity during mitochondrial stress." @default.
- W3026616846 created "2020-05-29" @default.
- W3026616846 creator A5026080576 @default.
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- W3026616846 creator A5084806589 @default.
- W3026616846 creator A5087550248 @default.
- W3026616846 creator A5089829367 @default.
- W3026616846 date "2020-05-20" @default.
- W3026616846 modified "2023-10-07" @default.
- W3026616846 title "Dynamic proteomics profiling of<i>Legionella pneumophila</i>infection unveils modulation of the host mitochondrial stress response pathway" @default.
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