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• W3026626577 abstract "Abstract Pangenome analyses are increasingly being utilized to study the evolution of eukaryotic organisms, which is often governed by variable gene content. While pangenomes can provide insight into polymorphic gene content, inferences about the ecological and adaptive potential of such organisms also need to be accompanied by additional supportive genomic analyses. In this study we constructed a pangenome of Claviceps purpurea from 24 genomes and examined the positive selection and recombination landscape of an economically important fungal organism for pharmacology and agricultural research. Together, these analyses revealed that C. purpurea has a relatively large accessory genome (∼ 38%) that is likely maintained by high recombination rates (ρ = 0.044) and transposon mediated gene duplication. However, due to observations of relatively low transposable element (TE) content (8.8%) and a lack of variability in genome sizes, prolific TE expansion is likely controlled by these high recombination rates, which may additionally be influencing the overall trend of purifying selection across the genome. Despite this trend, we observed a strong positive selection pressure on secondary metabolite genes, particularly within the ergoline biosynthetic cluster where we also revealed that the lpsA1 and lpsA2 genes were the result of a recombination event. These results indicate that secondary metabolites are primary factors affecting the diversification of the species into new ecological niches and help maintain its global distribution and broad host range. These results showcase the use of selection and recombination landscapes to identify mechanisms contributing to pangenome structure and primary factors influencing the evolution of an organism. Author Summary The use of genomic data to better understand the lifestyle of a pathogen and its relationship with its host has expanded our ability to investigate the evolutionary history of these organisms. This in turn has allowed us to decipher and understand the ambiguity surrounding the true nature of the fungal plant pathogen Claviceps purpurea . By combining three different types of broad genomic analyses we identified primary factors affecting the evolution and adaptive potential of this pathogen; particularly a large accessory genome, high recombination rates, and positive selection of genes associated with stress tolerance. These factors likely contribute to the pathogen’s global distribution and broad host range. Furthermore, these findings will influence the direction of future research into optimal control methods." @default.
• W3026626577 created "2020-05-29" @default.
• W3026626577 creator A5000840297 @default.
• W3026626577 creator A5009992437 @default.
• W3026626577 creator A5019685128 @default.
• W3026626577 creator A5054421485 @default.
• W3026626577 creator A5062511833 @default.
• W3026626577 date "2020-05-23" @default.
• W3026626577 modified "2023-10-01" @default.
• W3026626577 title "A large accessory genome, high recombination rates, and selection of secondary metabolite genes help maintain global distribution and broad host range of the fungal plant pathogen Claviceps purpurea" @default.
• W3026626577 cites W118055519 @default.
• W3026626577 cites W1482190741 @default.
• W3026626577 cites W1551835370 @default.
• W3026626577 cites W1608078211 @default.
• W3026626577 cites W1727424373 @default.
• W3026626577 cites W1920973730 @default.
• W3026626577 cites W1969418158 @default.
• W3026626577 cites W1982530526 @default.
• W3026626577 cites W1991176351 @default.
• W3026626577 cites W2000940414 @default.
• W3026626577 cites W2030909449 @default.
• W3026626577 cites W2031488725 @default.
• W3026626577 cites W2036134170 @default.
• W3026626577 cites W2041109359 @default.
• W3026626577 cites W2043180239 @default.
• W3026626577 cites W2053198008 @default.
• W3026626577 cites W2054254276 @default.
• W3026626577 cites W2065234888 @default.
• W3026626577 cites W2070097648 @default.
• W3026626577 cites W2070342831 @default.
• W3026626577 cites W2072090665 @default.
• W3026626577 cites W2082330286 @default.
• W3026626577 cites W2083929090 @default.
• W3026626577 cites W2093692235 @default.
• W3026626577 cites W2101291993 @default.
• W3026626577 cites W2108240161 @default.
• W3026626577 cites W2110335151 @default.
• W3026626577 cites W2112132489 @default.
• W3026626577 cites W2115011276 @default.
• W3026626577 cites W2115901407 @default.
• W3026626577 cites W2118384800 @default.
• W3026626577 cites W2120332203 @default.
• W3026626577 cites W2123678334 @default.
• W3026626577 cites W2123726318 @default.
• W3026626577 cites W2124088653 @default.
• W3026626577 cites W2124351063 @default.
• W3026626577 cites W2125177426 @default.
• W3026626577 cites W2129454675 @default.
• W3026626577 cites W2130582949 @default.
• W3026626577 cites W2131057787 @default.
• W3026626577 cites W2132926880 @default.
• W3026626577 cites W2133427989 @default.
• W3026626577 cites W2141052558 @default.
• W3026626577 cites W2141555372 @default.
• W3026626577 cites W2144504271 @default.
• W3026626577 cites W2144907970 @default.
• W3026626577 cites W2152418634 @default.
• W3026626577 cites W2152770371 @default.
• W3026626577 cites W2154775341 @default.
• W3026626577 cites W2159318793 @default.
• W3026626577 cites W2167493116 @default.
• W3026626577 cites W2169782843 @default.
• W3026626577 cites W2169859562 @default.
• W3026626577 cites W2230059391 @default.
• W3026626577 cites W2308012673 @default.
• W3026626577 cites W2340261577 @default.
• W3026626577 cites W2403923438 @default.
• W3026626577 cites W2468537156 @default.
• W3026626577 cites W2470678665 @default.
• W3026626577 cites W2580023202 @default.
• W3026626577 cites W2602439962 @default.
• W3026626577 cites W2604817691 @default.
• W3026626577 cites W2609207099 @default.
• W3026626577 cites W2609431831 @default.
• W3026626577 cites W2711772813 @default.
• W3026626577 cites W2731502325 @default.
• W3026626577 cites W2743905876 @default.
• W3026626577 cites W2769449671 @default.
• W3026626577 cites W2777140368 @default.
• W3026626577 cites W2784027642 @default.
• W3026626577 cites W2787339353 @default.
• W3026626577 cites W2791700655 @default.
• W3026626577 cites W2800965817 @default.
• W3026626577 cites W2804063886 @default.
• W3026626577 cites W2806914715 @default.
• W3026626577 cites W2905176963 @default.
• W3026626577 cites W2942829220 @default.
• W3026626577 cites W2951829171 @default.
• W3026626577 cites W2963876646 @default.
• W3026626577 cites W2972345212 @default.
• W3026626577 cites W2978897292 @default.
• W3026626577 cites W2988396470 @default.
• W3026626577 cites W3006200970 @default.
• W3026626577 cites W3007570075 @default.
• W3026626577 cites W3098725165 @default.
• W3026626577 cites W4253236113 @default.
• W3026626577 cites W610160850 @default.
• W3026626577 cites W614066952 @default.
• W3026626577 cites W746467347 @default.
• W3026626577 doi "https://doi.org/10.1101/2020.05.20.106880" @default.

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