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- W3026630602 abstract "Dendritic cells (DC) are key phagocytic cells that play crucial roles in both the innate and adaptive immune responses against the human immunodeficiency virus type 1 (HIV-1). By processing and presenting pathogen-derived antigens, dendritic cells initiate a directed response against infected cells. They activate the adaptive immune system upon recognition of pathogen-associated molecular patterns (PAMPs) on infected cells. During the course of HIV-1 infection, a successful adaptive (cytotoxic CD8 + T-cell) response is necessary for preventing the progression and spread of infection in a variety of cells. Dendritic cells have thus been recognized as a valuable tool in the development of immunotherapeutic approaches and vaccines effective against HIV-1. The advancements in dendritic cell vaccines in cancers have paved the way for applications of this form of immunotherapy to HIV-1 infection. Clinical trials with patients infected with HIV-1 who are well-suppressed by antiretroviral therapy (ART) were recently performed to assess the efficacy of DC vaccines, with the goal of mounting an HIV-1 antigen-specific T-cell response, ideally to clear infection and eliminate the need for long-term ART. This review summarizes and compares methods and efficacies of a number of DC vaccine trials utilizing autologous dendritic cells loaded with HIV-1 antigens. The potential for advancement and novel strategies of improving efficacy of this type of immunotherapy is also discussed." @default.
- W3026630602 created "2020-05-29" @default.
- W3026630602 creator A5001649068 @default.
- W3026630602 creator A5022931474 @default.
- W3026630602 creator A5034130608 @default.
- W3026630602 creator A5034657105 @default.
- W3026630602 creator A5067145311 @default.
- W3026630602 date "2020-05-25" @default.
- W3026630602 modified "2023-10-17" @default.
- W3026630602 title "The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook" @default.
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