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- W3026634857 abstract "Gliomas account for 75% of the primary malignant brain tumors and a majority of lower-grade gliomas (LGG) inevitably develop into glioblastoma. The dysregulation of lncRNAs play a crucial role in LGG. In the present study, we first screened out six differentially expressed lncRNAs (AC021739.2, AL031722.1, AL354740.1, FGD5-AS1, LINC00844, and NEAT1) based on TCGA and GTEx RNA-seq databases. LncRNA prognostic signature was then established by Kaplan–Meier and multivariate Cox proportional hazards regression, with its predictive value validated by time-dependent receiver operating characteristic (ROC) curves. After lncRNA-miRNA-mRNA regulatory networks were established by Cytoscape 3.7.2, Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed, with results enriched in various malignancy-related functions and pathways. Finally, six putative drugs (irinotecan, camptothecin, mitoxantrone, azacitidine, mestranol, and enilconazole) were predicted by Connectivity Map. In conclusion, we identified a 6-lncRNA prognostic signature with its ceRNA networks, and six candidate drugs against LGG. • Long non-coding RNAs play a crucial role in lower grade glioma • Integrated bioinformatics analysis to establish a six-lncRNA risk signature • Construct ceRNA networks with functional annotation • Predict putative small molecular drugs for lower grade glioma" @default.
- W3026634857 created "2020-05-29" @default.
- W3026634857 creator A5016049283 @default.
- W3026634857 creator A5082907894 @default.
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- W3026634857 date "2020-09-01" @default.
- W3026634857 modified "2023-09-26" @default.
- W3026634857 title "Identification and validation of a six-lncRNA prognostic signature with its ceRNA networks and candidate drugs in lower-grade gliomas" @default.
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- W3026634857 doi "https://doi.org/10.1016/j.ygeno.2020.05.016" @default.
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