FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026654709> ?p ?o ?g. }

• W3026654709 endingPage "10758" @default.
• W3026654709 startingPage "10751" @default.
• W3026654709 abstract "Breast cancer is one of the most common gynecological malignant tumors, the main reason of treatment failure is distant metastasis and local recurrence. TGF-β1 as a versatile polypeptide molecule plays an important role in inducing EMT to promote tumor invasion and metastasis. This study aims to investigate the effect of TGF-β1 on cisplatin (DDP) inhibiting the proliferation, migration and invasion of breast cancer and its correlation with EMT. TGF-β1 siRNA were transfected into MCF-7 cells. The cell morphology, proliferation, migration and invasion ability changes were detected by inverted microscope, clone formation assay, cell adhesion assay and Transwell Chamber Invasion. The expression of E-cadherin, vimentin, α-SMA were detected by Western blot. The results showed that TGF-β1 siRNA were transfected into MCF-7 cells successfully (P<0.05). The inhibitory activity of cisplatin on cell proliferation, migration and invasion of breast cancer were significantly enhanced after TGF-β1 siRNA transfection (P<0.05). The expression of E-cadherin was up-regulated, and vimentin and α-SMA were down-regulated with TGF-β1 siRNA transfection (P<0.05). Therefore, we concluded that TGF-β1 gene silencing can enhance the sensitivity of breast cancer to cisplatin on proliferation, migration and invasion partially by restraining the occurrence of EMT." @default.
• W3026654709 created "2020-05-29" @default.
• W3026654709 creator A5011544360 @default.
• W3026654709 creator A5019954143 @default.
• W3026654709 creator A5056248574 @default.
• W3026654709 creator A5066541476 @default.
• W3026654709 creator A5084833967 @default.
• W3026654709 creator A5088301101 @default.
• W3026654709 date "2017-01-01" @default.
• W3026654709 modified "2023-09-25" @default.
• W3026654709 title "TGF-β1 gene silencing can enhances the sensitivity of breast cancer to cisplatin partially by restraining the occurrence of EMT." @default.
• W3026654709 cites W121078932 @default.
• W3026654709 cites W2116472647 @default.
• W3026654709 cites W2187793946 @default.
• W3026654709 cites W2307410926 @default.
• W3026654709 cites W2463618150 @default.
• W3026654709 cites W2601164278 @default.
• W3026654709 cites W2605772805 @default.
• W3026654709 cites W2619665910 @default.
• W3026654709 cites W2622621620 @default.
• W3026654709 cites W2622823394 @default.
• W3026654709 cites W2623353693 @default.
• W3026654709 cites W2626035839 @default.
• W3026654709 cites W2674502410 @default.
• W3026654709 cites W2986398810 @default.
• W3026654709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6965821" @default.
• W3026654709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31966418" @default.
• W3026654709 hasPublicationYear "2017" @default.
• W3026654709 type Work @default.
• W3026654709 sameAs 3026654709 @default.
• W3026654709 citedByCount "0" @default.
• W3026654709 crossrefType "journal-article" @default.
• W3026654709 hasAuthorship W3026654709A5011544360 @default.
• W3026654709 hasAuthorship W3026654709A5019954143 @default.
• W3026654709 hasAuthorship W3026654709A5056248574 @default.
• W3026654709 hasAuthorship W3026654709A5066541476 @default.
• W3026654709 hasAuthorship W3026654709A5084833967 @default.
• W3026654709 hasAuthorship W3026654709A5088301101 @default.
• W3026654709 hasConcept C104317684 @default.
• W3026654709 hasConcept C118131993 @default.
• W3026654709 hasConcept C119056186 @default.
• W3026654709 hasConcept C11957725 @default.
• W3026654709 hasConcept C121608353 @default.
• W3026654709 hasConcept C126322002 @default.
• W3026654709 hasConcept C137738243 @default.
• W3026654709 hasConcept C142724271 @default.
• W3026654709 hasConcept C147447768 @default.
• W3026654709 hasConcept C1491633281 @default.
• W3026654709 hasConcept C185592680 @default.
• W3026654709 hasConcept C203014093 @default.
• W3026654709 hasConcept C204232928 @default.
• W3026654709 hasConcept C2776694085 @default.
• W3026654709 hasConcept C2778239845 @default.
• W3026654709 hasConcept C2779013556 @default.
• W3026654709 hasConcept C502942594 @default.
• W3026654709 hasConcept C530470458 @default.
• W3026654709 hasConcept C54009773 @default.
• W3026654709 hasConcept C54355233 @default.
• W3026654709 hasConcept C55493867 @default.
• W3026654709 hasConcept C62112901 @default.
• W3026654709 hasConcept C71924100 @default.
• W3026654709 hasConcept C81885089 @default.
• W3026654709 hasConcept C86803240 @default.
• W3026654709 hasConcept C95444343 @default.
• W3026654709 hasConceptScore W3026654709C104317684 @default.
• W3026654709 hasConceptScore W3026654709C118131993 @default.
• W3026654709 hasConceptScore W3026654709C119056186 @default.
• W3026654709 hasConceptScore W3026654709C11957725 @default.
• W3026654709 hasConceptScore W3026654709C121608353 @default.
• W3026654709 hasConceptScore W3026654709C126322002 @default.
• W3026654709 hasConceptScore W3026654709C137738243 @default.
• W3026654709 hasConceptScore W3026654709C142724271 @default.
• W3026654709 hasConceptScore W3026654709C147447768 @default.
• W3026654709 hasConceptScore W3026654709C1491633281 @default.
• W3026654709 hasConceptScore W3026654709C185592680 @default.
• W3026654709 hasConceptScore W3026654709C203014093 @default.
• W3026654709 hasConceptScore W3026654709C204232928 @default.
• W3026654709 hasConceptScore W3026654709C2776694085 @default.
• W3026654709 hasConceptScore W3026654709C2778239845 @default.
• W3026654709 hasConceptScore W3026654709C2779013556 @default.
• W3026654709 hasConceptScore W3026654709C502942594 @default.
• W3026654709 hasConceptScore W3026654709C530470458 @default.
• W3026654709 hasConceptScore W3026654709C54009773 @default.
• W3026654709 hasConceptScore W3026654709C54355233 @default.
• W3026654709 hasConceptScore W3026654709C55493867 @default.
• W3026654709 hasConceptScore W3026654709C62112901 @default.
• W3026654709 hasConceptScore W3026654709C71924100 @default.
• W3026654709 hasConceptScore W3026654709C81885089 @default.
• W3026654709 hasConceptScore W3026654709C86803240 @default.
• W3026654709 hasConceptScore W3026654709C95444343 @default.
• W3026654709 hasIssue "11" @default.
• W3026654709 hasLocation W30266547091 @default.
• W3026654709 hasOpenAccess W3026654709 @default.
• W3026654709 hasPrimaryLocation W30266547091 @default.
• W3026654709 hasRelatedWork W2068616967 @default.
• W3026654709 hasRelatedWork W2318119638 @default.
• W3026654709 hasRelatedWork W2365886735 @default.
• W3026654709 hasRelatedWork W2386344383 @default.

• next