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- W3026788161 abstract "A study was performed with the objective of extending the evidence that indicates that dietary boron affects calcium metabolism in humans. Five mean, five women on estrogen therapy, four postmenopausal women not on estrogen therapy, and one premenopausal women were fed a mixed Western basal diet that supplied 706 mg of calcium, 115 mg of magnesium, and 0.23 mg of boron with a 2,000-kcal intake. After an equilibration period of 14 days when dietary boron was about 3.23 mg/day, the subjects were fed the basal diet only for 63 days and then fed the basal diet plus 3 mg/day of boron as sodium borate for 49 days. When compared between the last 42 days of depletion and the last 35 days of repletion, several blood variables associated with calcium metabolism or status were significant different (P < 0.05). When all 15 subjects were used in the comparisons, plasma-ionized calcium (4.91 vs. 4.98 mg/dl) and serum 25-hydroxycholecalciferol (29.1 vs. 32.3 ng/ml) were lower, and serum calcitonin (74.1 vs. 59.0 pg/mg) and serum osteocalcin (3.4 vs. 2.5 ng/ml) were higher, during boron depletion than boron repletion. The postmenopausal women on estrogen therapy exhibited higher plasma-ionized calcium and serum 25-hydroxycholecalciferol and lower serum calcitonin and osteocalcin than did the men or postmenopausal women not on estrogen therapy. Boron supplementation apparently changed or tended to change those variables in a manner similar to that caused by estrogen therapy. Thus, the findings indicate that boron is beneficial, or essential, for optimal calcium metabolism and in the prevention of bone loss which occurs in postmenopausal women and older men." @default.
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- W3026788161 date "1990-01-01" @default.
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- W3026788161 title "Effect of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium-low diet" @default.
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