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• W3026800526 abstract "Abstract Low-density lipoprotein receptor-related protein 1 (LRP1) is a large, endocytic cell surface receptor that is highly expressed by oligodendrocyte progenitor cells (OPCs), and LRP1 expression is rapidly downregulated as OPCs differentiate into oligodendrocytes (OLs). We report that the conditional deletion of Lrp1 from adult mouse OPCs ( Pdgfrα-CreER :: Lrp1 fl/fl ) increases the number of new myelinating OLs added to brain, but that each new cell elaborates a normal quantity of myelin. OPC proliferation is also elevated following Lrp1 deletion in vivo , however, this is likely to be a secondary, homeostatic response to increased OPC differentiation, as our in vitro experiments show that LRP1 is a direct negative regulator of OPC differentiation, not proliferation. Deleting Lrp1 from adult OPCs also enhances remyelination, as cuprizone-induced lesions are smaller in Lrp1 -deleted mice, and parenchymal OPCs produce a larger number of mature OLs. These data suggest that the selective blockade of LRP1 function on adult OPCs may enhance myelin repair in demyelinating diseases, such as multiple sclerosis." @default.
• W3026800526 created "2020-05-29" @default.
• W3026800526 creator A5000642361 @default.
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• W3026800526 creator A5074702201 @default.
• W3026800526 date "2020-05-22" @default.
• W3026800526 modified "2023-10-16" @default.
• W3026800526 title "Low-density lipoprotein receptor-related protein 1 (LRP1) is a negative regulator of oligodendrocyte progenitor cell differentiation in the adult mouse brain" @default.
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• W3026800526 doi "https://doi.org/10.1101/2020.05.21.108209" @default.
• W3026800526 hasPublicationYear "2020" @default.
• W3026800526 type Work @default.
• W3026800526 sameAs 3026800526 @default.

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