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- W3026804957 abstract "Somatic changes during adolescence were related in this study to the breast or genitalia maturational ratings described by Tanner[ 1 ]. The mechanism of this induction is uncertain. LH receptor populations do not appear to change during FSH exposure. Urinary androsterone excretion in boys as well as in girls paralleled more the development of skeletal age as a maturational parameter than the chronological age of the adolescent individuals. Sex differences became obvious in relating the androsterone excretion in boys or girls to the skeletal maturity. A similar relationship between girls and boys to the skeletal development was encountered measuring testosterone excretion values. Plasma estradiol and estrone concentrations in girls and plasma testosterone and dihydrotestosterone levels in boys exhibited close correlations to the pubertal developmental stages. Estradiol levels in boys were highly correlated to testosterone concentrations, indicating that perhaps a significant portion of the estrogen is derived from circulating androgens. 5α-androstane-3α, 17β-diol showed a rise during the maturational stages in boys. Changes in the relationship between dihydrotestosterone/testosterone and androstanediol/testosterone indicate that there is an increment of 5α-reductase activity at the beginning of puberty. Longitudinal studies revealed parallelism between testosterone excretion in the urine and the plasma testosterone concentrations, showing the most marked increments between ages 12 and 14 years. In the rat it was found that plasma testosterone levels rose dramatically after the 25th day of life, the surge in dihydrotestosterone occurred at the 26th day of life, but the peak is reached later. These changes were compared to LH and FSH levels. The rate of increment in plasma FSH concentrations is greatest between 16 and 20 days of age and followed by a spurt in the LH concentration after day 20 of age. The abrupt rise in plasma testosterone seen after day 26 is perhaps mediated by the sudden rise in the two gonadotropins. Changes due to castration and cryptorchidism are discussed." @default.
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- W3026804957 date "1976-01-01" @default.
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- W3026804957 title "SEX STEROID HORMONES DURING MULTIPHASE PUBERTAL DEVELOPMENTS" @default.
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- W3026804957 doi "https://doi.org/10.1016/b978-0-08-019682-4.50113-x" @default.
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