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- W3026852235 endingPage "1239" @default.
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- W3026852235 abstract "Abstract The precise localization of CaV2 voltage-gated calcium channels at the synapse active zone requires various interacting proteins, of which, Rab3-interacting molecule or RIM is considered particularly important. In vertebrates, RIM interacts with CaV2 channels in vitro via a PDZ domain that binds to the extreme C-termini of the channels at acidic ligand motifs of D/E-D/E/H-WC-COOH, and knockout of RIM in vertebrates and invertebrates disrupts CaV2 channel synaptic localization and synapse function. Here, we describe a previously uncharacterized clade of RIM proteins bearing domain architectures homologous to those of known RIM homologs, but with some notable differences including key amino acids associated with PDZ domain ligand specificity. This novel RIM emerged near the stem lineage of metazoans and underwent extensive losses, but is retained in select animals including the early-diverging placozoan Trichoplax adhaerens, and molluscs. RNA expression and localization studies in Trichoplax and the mollusc snail Lymnaea stagnalis indicate differential regional/tissue type expression, but overlapping expression in single isolated neurons from Lymnaea. Ctenophores, the most early-diverging animals with synapses, are unique among animals with nervous systems in that they lack the canonical RIM, bearing only the newly identified homolog. Through phylogenetic analysis, we find that CaV2 channel D/E-D/E/H-WC-COOH like PDZ ligand motifs were present in the common ancestor of cnidarians and bilaterians, and delineate some deeply conserved C-terminal structures that distinguish CaV1 from CaV2 channels, and CaV1/CaV2 from CaV3 channels." @default.
- W3026852235 created "2020-05-29" @default.
- W3026852235 creator A5002594280 @default.
- W3026852235 creator A5023623577 @default.
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- W3026852235 creator A5055228577 @default.
- W3026852235 creator A5064592101 @default.
- W3026852235 creator A5064652325 @default.
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- W3026852235 creator A5075701359 @default.
- W3026852235 creator A5077088676 @default.
- W3026852235 creator A5081734923 @default.
- W3026852235 creator A5083162505 @default.
- W3026852235 date "2020-05-15" @default.
- W3026852235 modified "2023-10-01" @default.
- W3026852235 title "Early Metazoan Origin and Multiple Losses of a Novel Clade of RIM Presynaptic Calcium Channel Scaffolding Protein Homologs" @default.
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