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- W3026854597 endingPage "629" @default.
- W3026854597 startingPage "620" @default.
- W3026854597 abstract "In eukaryotes, chromatin remodeling and post-translational modifications (PTMs) shape the local chromatin landscape to establish permissive and repressive regions within the genome, orchestrating transcription, replication, and DNA repair in concert with other epigenetic mechanisms. Though cellular nutrient signaling encompasses a huge number of pathways, recent attention has turned to the hypothesis that the metabolic state of the cell is communicated to the genome through the type and concentration of metabolites in the nucleus that are cofactors for chromatin-modifying enzymes. Importantly, both epigenetic and metabolic dysregulation are hallmarks of a range of diseases, and this metabolism-chromatin axis may yield a well of new therapeutic targets. In this Perspective, we highlight emerging themes in the inter-regulation of the genome and metabolism via chromatin, including nonenzymatic histone modifications arising from chemically reactive metabolites, the expansion of PTM diversity from cofactor-promiscuous chromatin-modifying enzymes, and evidence for the existence and importance of subnucleocytoplasmic metabolite pools." @default.
- W3026854597 created "2020-05-29" @default.
- W3026854597 creator A5023554326 @default.
- W3026854597 creator A5031060352 @default.
- W3026854597 date "2020-05-22" @default.
- W3026854597 modified "2023-10-17" @default.
- W3026854597 title "Chromatin as a key consumer in the metabolite economy" @default.
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