FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026860418> ?p ?o ?g. }

• W3026860418 abstract "Abstract Background Neutrophilic subtype asthma occurs in approximately 15–25% of the asthma cases and is associated with severe airflow obstruction, corticosteroid resistance. MicroRNA plays a vital role in regulating many immune processes, but how miRNA circuits coordinate airway inflammation during neutrophilic asthma is unclear. Methods To investigate the molecular mechanism of miR-223 in regulation of neutrophilic airway inflammation, miR-223 knockout mice were used to the OVA/CFA-induced neutrophilic asthma or treated with NLRP3 inhibitor and IL-1β receptor antagonist. Based on the results obtained, wide-type mice were subsequently treated with miR-223 agomirs or negative control agomirs, and the effects on airway inflammation were assessed using morphometric techniques, quantitative RT-PCR, western blot, ELISA and other molecular approaches. Results The expression of miR-223 was upregulated in lung tissues of experimental mice model. Furthermore, miR-223 −/− mice led to aggravated neutrophilic airway inflammation with heightened histopathological, inflammatory cells and cytokines readouts. Moreover, miR-223 −/− mice also presented with enhanced NLRP3 inflammasome level with elevated IL-1β. Blocking NLRP3 or IL-1β diminished this phenotype. Finally, overexpression of miR-223 via treatment with miR-223 agomirs attenuated airway inflammation, NLRP3 levels and IL-1β release. Conclusions The findings of this study revealed a crucial role for miR-223 in regulating the immunoinflammatory responses by depressing the NLRP3/ IL-1β axis in neutrophilic asthma." @default.
• W3026860418 created "2020-05-29" @default.
• W3026860418 creator A5010008442 @default.
• W3026860418 creator A5035101566 @default.
• W3026860418 creator A5042007093 @default.
• W3026860418 creator A5084708534 @default.
• W3026860418 date "2020-05-18" @default.
• W3026860418 modified "2023-10-18" @default.
• W3026860418 title "MiR-223 plays a protecting role in neutrophilic asthmatic mice through the inhibition of NLRP3 inflammasome" @default.
• W3026860418 cites W1882905539 @default.
• W3026860418 cites W1884621467 @default.
• W3026860418 cites W1969430735 @default.
• W3026860418 cites W1975782878 @default.
• W3026860418 cites W1978995149 @default.
• W3026860418 cites W1999716006 @default.
• W3026860418 cites W2007031153 @default.
• W3026860418 cites W2014869583 @default.
• W3026860418 cites W2014974499 @default.
• W3026860418 cites W2016379610 @default.
• W3026860418 cites W2019317799 @default.
• W3026860418 cites W2021701428 @default.
• W3026860418 cites W2022928437 @default.
• W3026860418 cites W2027746633 @default.
• W3026860418 cites W2029967901 @default.
• W3026860418 cites W2033566559 @default.
• W3026860418 cites W2034004675 @default.
• W3026860418 cites W2034058980 @default.
• W3026860418 cites W2037509102 @default.
• W3026860418 cites W2045233192 @default.
• W3026860418 cites W2048178760 @default.
• W3026860418 cites W2053208368 @default.
• W3026860418 cites W2069277889 @default.
• W3026860418 cites W2072918543 @default.
• W3026860418 cites W2079625864 @default.
• W3026860418 cites W2080595107 @default.
• W3026860418 cites W2102952012 @default.
• W3026860418 cites W2106293827 @default.
• W3026860418 cites W2111031301 @default.
• W3026860418 cites W2112486153 @default.
• W3026860418 cites W2115711076 @default.
• W3026860418 cites W2120052164 @default.
• W3026860418 cites W2126515688 @default.
• W3026860418 cites W2151114382 @default.
• W3026860418 cites W2157503340 @default.
• W3026860418 cites W2158045379 @default.
• W3026860418 cites W2158507525 @default.
• W3026860418 cites W2159638894 @default.
• W3026860418 cites W2162674813 @default.
• W3026860418 cites W2167362045 @default.
• W3026860418 cites W2286216520 @default.
• W3026860418 cites W2310292662 @default.
• W3026860418 cites W2345371524 @default.
• W3026860418 cites W2557613735 @default.
• W3026860418 cites W2582861287 @default.
• W3026860418 cites W2593240146 @default.
• W3026860418 cites W2599577037 @default.
• W3026860418 cites W2613151721 @default.
• W3026860418 cites W2614615141 @default.
• W3026860418 cites W2736210440 @default.
• W3026860418 cites W2761624970 @default.
• W3026860418 cites W2766012038 @default.
• W3026860418 cites W2768403574 @default.
• W3026860418 cites W2791194021 @default.
• W3026860418 cites W2796676675 @default.
• W3026860418 cites W2796716208 @default.
• W3026860418 cites W2808631591 @default.
• W3026860418 cites W2886514991 @default.
• W3026860418 cites W2903068554 @default.
• W3026860418 cites W2929158016 @default.
• W3026860418 cites W2937583228 @default.
• W3026860418 cites W2946628549 @default.
• W3026860418 cites W4211182003 @default.
• W3026860418 cites W4211217520 @default.
• W3026860418 doi "https://doi.org/10.1186/s12931-020-01374-4" @default.
• W3026860418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7236263" @default.
• W3026860418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32423405" @default.
• W3026860418 hasPublicationYear "2020" @default.
• W3026860418 type Work @default.
• W3026860418 sameAs 3026860418 @default.
• W3026860418 citedByCount "34" @default.
• W3026860418 countsByYear W30268604182020 @default.
• W3026860418 countsByYear W30268604182021 @default.
• W3026860418 countsByYear W30268604182022 @default.
• W3026860418 countsByYear W30268604182023 @default.
• W3026860418 crossrefType "journal-article" @default.
• W3026860418 hasAuthorship W3026860418A5010008442 @default.
• W3026860418 hasAuthorship W3026860418A5035101566 @default.
• W3026860418 hasAuthorship W3026860418A5042007093 @default.
• W3026860418 hasAuthorship W3026860418A5084708534 @default.
• W3026860418 hasBestOaLocation W30268604181 @default.
• W3026860418 hasConcept C104317684 @default.
• W3026860418 hasConcept C126322002 @default.
• W3026860418 hasConcept C127561419 @default.
• W3026860418 hasConcept C170493617 @default.
• W3026860418 hasConcept C182704531 @default.
• W3026860418 hasConcept C203014093 @default.
• W3026860418 hasConcept C2776042228 @default.
• W3026860418 hasConcept C2776914184 @default.
• W3026860418 hasConcept C2777209026 @default.
• W3026860418 hasConcept C33362165 @default.

• next