FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026884999> ?p ?o ?g. }

• W3026884999 endingPage "456" @default.
• W3026884999 startingPage "456" @default.
• W3026884999 abstract "Background: It has been suggested that circulating Paraoxonase-1 (PON1) and apolipoprotein A1 (APOA1), which closely interacts with the antioxidant enzyme, could be implicated in Alzheimer’s disease (AD) and vascular dementia (VaD) development. This study aimed to evaluate PON1 changes in serum and cerebrospinal fluid (CSF) as evidence for its association with AD or VaD. Methods: Serum PON-arylesterase activity was measured in patients with AD, VaD, and CONTROLS distributed in two cohorts: Ferrara cohort (FC: n = 503, age = 74 years) and Amsterdam Dementia cohort (ADC: n = 71, age = 65 years). In the last cohort, CSF PON-arylesterase, CSF β-amyloid1-42, p-tau and t-tau, and imaging biomarkers were also measured. Results: AD and VaD patients of FC showed significantly lower levels of serum PON-arylesterase compared to CONTROLS, but this outcome was driven by older subjects (>71 years, p < 0.0001). In the younger ADC, a similar decreasing (but not significant) trend was observed in serum and CSF. Intriguingly, PON-arylesterase per APOA1 correlated with t-tau in AD group (r = −0.485, p = 0.002). Conclusion: These results suggest that decreased peripheral PON-arylesterase might be a specific feature of older AD/VaD patients. Moreover, we showed that PON-arylesterase/APOA1 is inversely related to neurodegeneration in AD patients, suggesting a prognostic usefulness of this composite parameter." @default.
• W3026884999 created "2020-05-29" @default.
• W3026884999 creator A5030471925 @default.
• W3026884999 creator A5033091395 @default.
• W3026884999 creator A5038926287 @default.
• W3026884999 creator A5044479443 @default.
• W3026884999 creator A5050386316 @default.
• W3026884999 creator A5063528039 @default.
• W3026884999 creator A5075394738 @default.
• W3026884999 date "2020-05-25" @default.
• W3026884999 modified "2023-10-11" @default.
• W3026884999 title "Arylesterase Activity of Paraoxonase-1 in Serum and Cerebrospinal Fluid of Patients with Alzheimer’s Disease and Vascular Dementia" @default.
• W3026884999 cites W1577433680 @default.
• W3026884999 cites W1869060308 @default.
• W3026884999 cites W1900968643 @default.
• W3026884999 cites W1908864498 @default.
• W3026884999 cites W1925587073 @default.
• W3026884999 cites W1966387527 @default.
• W3026884999 cites W1966802394 @default.
• W3026884999 cites W1978064757 @default.
• W3026884999 cites W1979218016 @default.
• W3026884999 cites W2001065761 @default.
• W3026884999 cites W2005031405 @default.
• W3026884999 cites W2005434943 @default.
• W3026884999 cites W2011267119 @default.
• W3026884999 cites W2021966311 @default.
• W3026884999 cites W2032440627 @default.
• W3026884999 cites W2035892177 @default.
• W3026884999 cites W2036433301 @default.
• W3026884999 cites W2042718903 @default.
• W3026884999 cites W2048505725 @default.
• W3026884999 cites W2048756000 @default.
• W3026884999 cites W2059152389 @default.
• W3026884999 cites W2083626706 @default.
• W3026884999 cites W2085222803 @default.
• W3026884999 cites W2086373293 @default.
• W3026884999 cites W2094401907 @default.
• W3026884999 cites W2099476725 @default.
• W3026884999 cites W2100283192 @default.
• W3026884999 cites W2112150247 @default.
• W3026884999 cites W2115017507 @default.
• W3026884999 cites W2118416292 @default.
• W3026884999 cites W2129497119 @default.
• W3026884999 cites W2136838641 @default.
• W3026884999 cites W2161414810 @default.
• W3026884999 cites W2165773859 @default.
• W3026884999 cites W2166691340 @default.
• W3026884999 cites W2175680864 @default.
• W3026884999 cites W2233978156 @default.
• W3026884999 cites W2254923557 @default.
• W3026884999 cites W2319392014 @default.
• W3026884999 cites W2433619092 @default.
• W3026884999 cites W2474981734 @default.
• W3026884999 cites W2527609605 @default.
• W3026884999 cites W2533499860 @default.
• W3026884999 cites W2563243861 @default.
• W3026884999 cites W2746251217 @default.
• W3026884999 cites W2749494518 @default.
• W3026884999 cites W2751275923 @default.
• W3026884999 cites W2760285987 @default.
• W3026884999 cites W2774314613 @default.
• W3026884999 cites W2786608785 @default.
• W3026884999 cites W2789493765 @default.
• W3026884999 cites W2911954535 @default.
• W3026884999 cites W2936811927 @default.
• W3026884999 cites W2947609180 @default.
• W3026884999 cites W2985909296 @default.
• W3026884999 cites W3010322762 @default.
• W3026884999 doi "https://doi.org/10.3390/antiox9050456" @default.
• W3026884999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7278748" @default.
• W3026884999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32466344" @default.
• W3026884999 hasPublicationYear "2020" @default.
• W3026884999 type Work @default.
• W3026884999 sameAs 3026884999 @default.
• W3026884999 citedByCount "14" @default.
• W3026884999 countsByYear W30268849992020 @default.
• W3026884999 countsByYear W30268849992021 @default.
• W3026884999 countsByYear W30268849992022 @default.
• W3026884999 countsByYear W30268849992023 @default.
• W3026884999 crossrefType "journal-article" @default.
• W3026884999 hasAuthorship W3026884999A5030471925 @default.
• W3026884999 hasAuthorship W3026884999A5033091395 @default.
• W3026884999 hasAuthorship W3026884999A5038926287 @default.
• W3026884999 hasAuthorship W3026884999A5044479443 @default.
• W3026884999 hasAuthorship W3026884999A5050386316 @default.
• W3026884999 hasAuthorship W3026884999A5063528039 @default.
• W3026884999 hasAuthorship W3026884999A5075394738 @default.
• W3026884999 hasBestOaLocation W30268849991 @default.
• W3026884999 hasConcept C104317684 @default.
• W3026884999 hasConcept C126322002 @default.
• W3026884999 hasConcept C134018914 @default.
• W3026884999 hasConcept C135763542 @default.
• W3026884999 hasConcept C2776151105 @default.
• W3026884999 hasConcept C2776509667 @default.
• W3026884999 hasConcept C2777952318 @default.
• W3026884999 hasConcept C2778163477 @default.
• W3026884999 hasConcept C2778242859 @default.
• W3026884999 hasConcept C2779134260 @default.

• next