Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026891921> ?p ?o ?g. }
- W3026891921 endingPage "108079" @default.
- W3026891921 startingPage "108079" @default.
- W3026891921 abstract "Previously, we have shown that Staphylococcus (S) aureus induces a glycolytic response in retinal residential (microglia) and infiltrated cells (neutrophils and macrophages) during endophthalmitis. In this study, we sought to investigate the physiological role of glycolysis in bacterial endophthalmitis using a glycolytic inhibitor, 2-deoxyglucose (2DG). Our data showed that 2DG treatment attenuated the inflammatory responses of mouse bone marrow-derived macrophages (BMDM) and neutrophils (BMDN) when challenged with either live or heat-killed S. aureus (HKSA). Among the inflammatory mediators, 2DG caused a significant reduction in levels of cytokines (TNF-α, IL-1β, IL-6) and chemokines (CXCL1 and CXCL2). Western blot analysis of 2DG treated cells showed downregulation of bacterial-induced MEK/ERK pathways. In vivo, intravitreal administration of 2DG both pre- and post-bacterial infection resulted in a significant reduction in intraocular inflammation in C57BL/6 mouse eyes and downregulation of ERK phosphorylation in retinal tissue. Collectively, our study demonstrates that 2DG attenuates inflammatory response in bacterial endophthalmitis and cultured innate immune cells via inhibition of ERK signaling. Thus glycolytic inhibitors in combination with antibiotics could mitigate inflammation-mediated tissue damage in ocular infections." @default.
- W3026891921 created "2020-05-29" @default.
- W3026891921 creator A5011132764 @default.
- W3026891921 creator A5019187851 @default.
- W3026891921 creator A5033377592 @default.
- W3026891921 creator A5072567284 @default.
- W3026891921 creator A5086871265 @default.
- W3026891921 date "2020-08-01" @default.
- W3026891921 modified "2023-10-18" @default.
- W3026891921 title "Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis" @default.
- W3026891921 cites W1571811411 @default.
- W3026891921 cites W1605882439 @default.
- W3026891921 cites W1622905562 @default.
- W3026891921 cites W1673799980 @default.
- W3026891921 cites W1747545298 @default.
- W3026891921 cites W1897687685 @default.
- W3026891921 cites W1974369116 @default.
- W3026891921 cites W1975202537 @default.
- W3026891921 cites W1985185645 @default.
- W3026891921 cites W1987186922 @default.
- W3026891921 cites W1999324987 @default.
- W3026891921 cites W2004177990 @default.
- W3026891921 cites W2017552562 @default.
- W3026891921 cites W2028303721 @default.
- W3026891921 cites W2031396061 @default.
- W3026891921 cites W2054162710 @default.
- W3026891921 cites W2062804078 @default.
- W3026891921 cites W2100039832 @default.
- W3026891921 cites W2100852795 @default.
- W3026891921 cites W2105265356 @default.
- W3026891921 cites W2128771042 @default.
- W3026891921 cites W2132658744 @default.
- W3026891921 cites W2140677484 @default.
- W3026891921 cites W2146791037 @default.
- W3026891921 cites W2154883084 @default.
- W3026891921 cites W2158240289 @default.
- W3026891921 cites W2162873738 @default.
- W3026891921 cites W2317995385 @default.
- W3026891921 cites W2338863436 @default.
- W3026891921 cites W2415215988 @default.
- W3026891921 cites W2468925656 @default.
- W3026891921 cites W2497171188 @default.
- W3026891921 cites W2513994159 @default.
- W3026891921 cites W2561706117 @default.
- W3026891921 cites W2580224021 @default.
- W3026891921 cites W2596650357 @default.
- W3026891921 cites W2740829994 @default.
- W3026891921 cites W2747770801 @default.
- W3026891921 cites W2772960486 @default.
- W3026891921 cites W2804151843 @default.
- W3026891921 cites W2884799708 @default.
- W3026891921 cites W2891097012 @default.
- W3026891921 cites W2916019914 @default.
- W3026891921 cites W2947578058 @default.
- W3026891921 cites W2970803381 @default.
- W3026891921 cites W2999345237 @default.
- W3026891921 cites W3000545901 @default.
- W3026891921 cites W3004362203 @default.
- W3026891921 cites W3004615920 @default.
- W3026891921 cites W3007037356 @default.
- W3026891921 doi "https://doi.org/10.1016/j.exer.2020.108079" @default.
- W3026891921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7484014" @default.
- W3026891921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32454039" @default.
- W3026891921 hasPublicationYear "2020" @default.
- W3026891921 type Work @default.
- W3026891921 sameAs 3026891921 @default.
- W3026891921 citedByCount "17" @default.
- W3026891921 countsByYear W30268919212020 @default.
- W3026891921 countsByYear W30268919212021 @default.
- W3026891921 countsByYear W30268919212022 @default.
- W3026891921 countsByYear W30268919212023 @default.
- W3026891921 crossrefType "journal-article" @default.
- W3026891921 hasAuthorship W3026891921A5011132764 @default.
- W3026891921 hasAuthorship W3026891921A5019187851 @default.
- W3026891921 hasAuthorship W3026891921A5033377592 @default.
- W3026891921 hasAuthorship W3026891921A5072567284 @default.
- W3026891921 hasAuthorship W3026891921A5086871265 @default.
- W3026891921 hasBestOaLocation W30268919212 @default.
- W3026891921 hasConcept C104317684 @default.
- W3026891921 hasConcept C127561419 @default.
- W3026891921 hasConcept C12823836 @default.
- W3026891921 hasConcept C13373296 @default.
- W3026891921 hasConcept C136449434 @default.
- W3026891921 hasConcept C179661763 @default.
- W3026891921 hasConcept C181199279 @default.
- W3026891921 hasConcept C20251656 @default.
- W3026891921 hasConcept C203014093 @default.
- W3026891921 hasConcept C2776914184 @default.
- W3026891921 hasConcept C2777235844 @default.
- W3026891921 hasConcept C54355233 @default.
- W3026891921 hasConcept C55493867 @default.
- W3026891921 hasConcept C57074206 @default.
- W3026891921 hasConcept C62478195 @default.
- W3026891921 hasConcept C86803240 @default.
- W3026891921 hasConcept C8891405 @default.
- W3026891921 hasConcept C89423630 @default.
- W3026891921 hasConcept C95444343 @default.
- W3026891921 hasConcept C96525457 @default.