FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3026901239> ?p ?o ?g. }

• W3026901239 abstract "Abstract Normal brain function is associated with an assortment of oscillations of various frequencies, each reflecting the timing of separate computational processes and levels of synchronization within and between brain areas. Stimulation accurately delivered on a specified phase of a given oscillation provides the opportunity to target individual aspects of brain function. To achieve this, we have developed a highly responsive system to produce a continuous online phase-estimate. In addition to stable oscillations, the system accurately tracks the early cycles of short, transient oscillations and can operate across the frequency range of most established neuronal oscillations (4 to 250 Hz). Here we demonstrate bidirectional modulation of the pathologically elevated parkinsonian beta-band oscillation (around 35 Hz) in 6-OHDA hemi-lesioned rats. Beta phase, monitored using a single channel electrocorticogram above secondary motor cortex, was used to drive electrical stimulation of the globus pallidus on one of eight phases spanning the oscillation cycle. Stimulation of the early ascending phase suppressed the oscillation whereas stimulation of the early descending phase was amplifying. By implementing a rule that prevented stimulation when the phase estimate was unstable, we achieved a system that could adapt stimulation rate and pattern to respond to the changes produced in the target oscillation. This allowed the electronic system to create and maintain a state of equilibrium with the biological system resulting in continuous stable modulation of the target oscillation over time. These results demonstrate the feasibility of phase locked stimulation as a more refined strategy for remediation of pathological beta oscillations in the treatment of the motor symptoms of Parkinson’s disease. Furthermore, they establish the utility of our algorithm and allow for the potential to assess the contribution of rhythmic activity in neuronal computation across a number of brain systems." @default.
• W3026901239 created "2020-05-29" @default.
• W3026901239 creator A5029031804 @default.
• W3026901239 creator A5033291138 @default.
• W3026901239 creator A5051775809 @default.
• W3026901239 date "2020-05-25" @default.
• W3026901239 modified "2023-10-17" @default.
• W3026901239 title "Phase-dependent closed-loop modulation of neural oscillations in vivo" @default.
• W3026901239 cites W1484585780 @default.
• W3026901239 cites W1498617277 @default.
• W3026901239 cites W1902335101 @default.
• W3026901239 cites W1968261149 @default.
• W3026901239 cites W1972879677 @default.
• W3026901239 cites W1973275441 @default.
• W3026901239 cites W2002699700 @default.
• W3026901239 cites W2008027377 @default.
• W3026901239 cites W2011431046 @default.
• W3026901239 cites W2026640911 @default.
• W3026901239 cites W2032337192 @default.
• W3026901239 cites W2040149530 @default.
• W3026901239 cites W2044750331 @default.
• W3026901239 cites W2048317486 @default.
• W3026901239 cites W2067393309 @default.
• W3026901239 cites W2106822551 @default.
• W3026901239 cites W2115452265 @default.
• W3026901239 cites W2119156931 @default.
• W3026901239 cites W2125545189 @default.
• W3026901239 cites W2130529454 @default.
• W3026901239 cites W2133746753 @default.
• W3026901239 cites W2141405085 @default.
• W3026901239 cites W2142875089 @default.
• W3026901239 cites W2143685192 @default.
• W3026901239 cites W2150135821 @default.
• W3026901239 cites W2152779992 @default.
• W3026901239 cites W2157586156 @default.
• W3026901239 cites W2158048307 @default.
• W3026901239 cites W2171030528 @default.
• W3026901239 cites W2229256208 @default.
• W3026901239 cites W2340466108 @default.
• W3026901239 cites W2406989723 @default.
• W3026901239 cites W2470901602 @default.
• W3026901239 cites W2515990420 @default.
• W3026901239 cites W2563867255 @default.
• W3026901239 cites W2599888381 @default.
• W3026901239 cites W2622294281 @default.
• W3026901239 cites W2764335780 @default.
• W3026901239 cites W2781661760 @default.
• W3026901239 cites W2886040293 @default.
• W3026901239 cites W2888204163 @default.
• W3026901239 cites W2896390313 @default.
• W3026901239 cites W2945496626 @default.
• W3026901239 cites W2951277489 @default.
• W3026901239 cites W2963352400 @default.
• W3026901239 cites W2964618399 @default.
• W3026901239 cites W2967189222 @default.
• W3026901239 cites W2971752039 @default.
• W3026901239 cites W3007482991 @default.
• W3026901239 cites W3012627763 @default.
• W3026901239 cites W3013063797 @default.
• W3026901239 doi "https://doi.org/10.1101/2020.05.21.102335" @default.
• W3026901239 hasPublicationYear "2020" @default.
• W3026901239 type Work @default.
• W3026901239 sameAs 3026901239 @default.
• W3026901239 citedByCount "9" @default.
• W3026901239 countsByYear W30269012392020 @default.
• W3026901239 countsByYear W30269012392021 @default.
• W3026901239 countsByYear W30269012392022 @default.
• W3026901239 countsByYear W30269012392023 @default.
• W3026901239 crossrefType "posted-content" @default.
• W3026901239 hasAuthorship W3026901239A5029031804 @default.
• W3026901239 hasAuthorship W3026901239A5033291138 @default.
• W3026901239 hasAuthorship W3026901239A5051775809 @default.
• W3026901239 hasBestOaLocation W30269012391 @default.
• W3026901239 hasConcept C111919701 @default.
• W3026901239 hasConcept C121332964 @default.
• W3026901239 hasConcept C123079801 @default.
• W3026901239 hasConcept C127162648 @default.
• W3026901239 hasConcept C154945302 @default.
• W3026901239 hasConcept C169760540 @default.
• W3026901239 hasConcept C17077164 @default.
• W3026901239 hasConcept C185592680 @default.
• W3026901239 hasConcept C24890656 @default.
• W3026901239 hasConcept C24998067 @default.
• W3026901239 hasConcept C2775924081 @default.
• W3026901239 hasConcept C2778439541 @default.
• W3026901239 hasConcept C2778562939 @default.
• W3026901239 hasConcept C2780799671 @default.
• W3026901239 hasConcept C41008148 @default.
• W3026901239 hasConcept C44280652 @default.
• W3026901239 hasConcept C47446073 @default.
• W3026901239 hasConcept C55493867 @default.
• W3026901239 hasConcept C62520636 @default.
• W3026901239 hasConcept C76155785 @default.
• W3026901239 hasConcept C86803240 @default.
• W3026901239 hasConceptScore W3026901239C111919701 @default.
• W3026901239 hasConceptScore W3026901239C121332964 @default.
• W3026901239 hasConceptScore W3026901239C123079801 @default.
• W3026901239 hasConceptScore W3026901239C127162648 @default.
• W3026901239 hasConceptScore W3026901239C154945302 @default.
• W3026901239 hasConceptScore W3026901239C169760540 @default.

• next