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- W3026936700 abstract "Amongst the advances made by steroid chemists has been the development of corticosteroids with exceptional topical activity. The use of such compounds in treating skin diseases is well known. More recently the effects of these compounds has been investigated on other body surfaces, particularly the mucous membranes lining the gut, the bronchi and nasal passages. Hopefully to demonstrate some separation of topical anti-inflammatory activity from systemic glucocorticoid effects. Their use in the gut has been disappointing as no useful separation of these effects has been observed. However, the administration of some of these steroids by inhalation to treat bronchial asthma or intra-nasally for rhinitis has recently been shown to be of therapeutic benefit and to demonstrate some separation of effects within the glucocorticoid function. Betamethasone-17-valerate and beclomethasone-17,21-dipropionate appear to demonstrate greater separation than two esters of dexamethasone which are also available as aerosols. Some of the properties of these four steroids have been investigated in man and are described." @default.
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- W3026936700 date "1976-01-01" @default.
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- W3026936700 title "PROPERTIES AND THERAPEUTIC USES OF SOME CORTICOSTEROIDS WITH ENHANCED TOPICAL POTENCY" @default.
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- W3026936700 doi "https://doi.org/10.1016/b978-0-08-019682-4.50092-5" @default.
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