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- W3026950574 abstract "Introduction: Carbapenemases producing Enterobacteriaceae (CRE)has recently drawn widespread attention.The increasing number of carbapenemase producing organisms in urinary tract infection (UTI) leaves very few treatment options for clinicians.This study was designed to evaluate carbapenemases producing Escherichia coli(E. coli)amongst hospitalized subjects suffering from urinary tract infection in a tertiary care center of Kathmandu, Nepal, between December 2013 and July 2014. Methods: Standard microbiological techniques were used for isolation and identification of the isolates.The antimicrobial susceptibility of bacterial isolates was determined following Clinical and Laboratory Standard Institute (CLSI) recommended Kirby-Bauer Disc Diffusion method. The defining criterion in this study for an isolate to be multi-drug resistant, resistance to at least one agent in three or more than three different structural classes was taken. Results: Among 1624 hospitalized patients enrolled, a total of 454 (25%) isolates were recovered. Of these combined disc method performed to detect Metallo-β-Lactamase (MBL) mediated isolates; the most common isolate was E.coli (n=276, 61%). Out of 276 E. coli isolates, 156 (57%) were multi-drug resistant isolates and 21 (7.6 %) of the isolates were resistant to carbapenems. All of carbapenem-resistant E. coli (CRE) were MDR. Significant drug resistances were observed among CRE compared to other MDR E. coli. ConclusIon: Our results demonstrate a high prevalence of carpabenemase producing E. coliin hospital settings.Carbapenemases in E. coli is a majorthreat.Early detection and surveillance of carbapenemase-producers routinely in clinical laboratoriesis necessary to facilitate effective infection control and to reduce the escalation of resistance." @default.
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- W3026950574 date "2017-09-09" @default.
- W3026950574 modified "2023-09-26" @default.
- W3026950574 title "Carbapenem-resistant Escherichia Coli Among the hospitalized Patients with urinary tract Infections in a tertiary care center of nepal" @default.
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