FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027088372> ?p ?o ?g. }

• W3027088372 endingPage "1733" @default.
• W3027088372 startingPage "1723" @default.
• W3027088372 abstract "Background Small cell lung cancer (SCLC) has the strongest association with smoking among lung cancers. The characteristics of never smokers with SCLC is not known. Research Question Are the clinical characteristics, prognostic factors, survival, genomic alterations, and tumor mutational burdens of SCLC in patients who have never smoked different from those who have smoked? Study Design and Methods A retrospective multicenter cohort study of patients with clinician-confirmed SCLC was performed with the use of a longitudinal and nationally representative electronic medical records database. Smoking history was assessed through technology-enabled abstraction and confirmed for never smokers via chart review. Genomic characteristics of never smoker patients with SCLC were examined with the use of a next-generation sequencing-based gene panel and whole exome sequencing. Results One hundred of 5,632 patients (1.8%) with SCLC were never smokers. Relative to smokers, never smokers were more likely to be female (66.0% vs 52.4%; P = .009) and present with extensive stage (70.0% vs 62.2%; P = .028). Never smokers had a higher proportion of patients in age groups 35 to 49 years (7.0% vs 3.0%; P = .006) and ≥80 years (17.0% vs 8.2%; P = .006). Known risk factors for lung cancer were found in <20% of never smokers. There were no overall survival differences between never smokers and smokers. Among patients with available genomic data (n = 9), never smoker SCLC were characterized by lower tumor mutational burden, a lower frequency of TP53 mutations, and an absence of mutational signatures related to tobacco exposure. Interpretation The sex- and age-specific distribution of SCLC among never smokers, along with differences that were identified by genomic analyses, suggests a distinct biology of SCLC in never smokers compared with smokers. Small cell lung cancer (SCLC) has the strongest association with smoking among lung cancers. The characteristics of never smokers with SCLC is not known. Are the clinical characteristics, prognostic factors, survival, genomic alterations, and tumor mutational burdens of SCLC in patients who have never smoked different from those who have smoked? A retrospective multicenter cohort study of patients with clinician-confirmed SCLC was performed with the use of a longitudinal and nationally representative electronic medical records database. Smoking history was assessed through technology-enabled abstraction and confirmed for never smokers via chart review. Genomic characteristics of never smoker patients with SCLC were examined with the use of a next-generation sequencing-based gene panel and whole exome sequencing. One hundred of 5,632 patients (1.8%) with SCLC were never smokers. Relative to smokers, never smokers were more likely to be female (66.0% vs 52.4%; P = .009) and present with extensive stage (70.0% vs 62.2%; P = .028). Never smokers had a higher proportion of patients in age groups 35 to 49 years (7.0% vs 3.0%; P = .006) and ≥80 years (17.0% vs 8.2%; P = .006). Known risk factors for lung cancer were found in <20% of never smokers. There were no overall survival differences between never smokers and smokers. Among patients with available genomic data (n = 9), never smoker SCLC were characterized by lower tumor mutational burden, a lower frequency of TP53 mutations, and an absence of mutational signatures related to tobacco exposure. The sex- and age-specific distribution of SCLC among never smokers, along with differences that were identified by genomic analyses, suggests a distinct biology of SCLC in never smokers compared with smokers." @default.
• W3027088372 created "2020-05-29" @default.
• W3027088372 creator A5001098397 @default.
• W3027088372 creator A5003384343 @default.
• W3027088372 creator A5009108088 @default.
• W3027088372 creator A5009327463 @default.
• W3027088372 creator A5017638182 @default.
• W3027088372 creator A5020366697 @default.
• W3027088372 creator A5022481842 @default.
• W3027088372 creator A5022594161 @default.
• W3027088372 creator A5027783041 @default.
• W3027088372 creator A5028085268 @default.
• W3027088372 creator A5039844485 @default.
• W3027088372 creator A5044148216 @default.
• W3027088372 creator A5045973874 @default.
• W3027088372 creator A5046205786 @default.
• W3027088372 creator A5048608729 @default.
• W3027088372 creator A5063153537 @default.
• W3027088372 creator A5066240023 @default.
• W3027088372 creator A5073288035 @default.
• W3027088372 creator A5074644543 @default.
• W3027088372 creator A5082372978 @default.
• W3027088372 creator A5083208432 @default.
• W3027088372 creator A5088809839 @default.
• W3027088372 creator A5090485561 @default.
• W3027088372 date "2020-10-01" @default.
• W3027088372 modified "2023-09-27" @default.
• W3027088372 title "Clinical and Genomic Characteristics of Small Cell Lung Cancer in Never Smokers" @default.
• W3027088372 cites W1903523058 @default.
• W3027088372 cites W1923410233 @default.
• W3027088372 cites W1964106115 @default.
• W3027088372 cites W1993272382 @default.
• W3027088372 cites W2003453766 @default.
• W3027088372 cites W2041992600 @default.
• W3027088372 cites W2065294258 @default.
• W3027088372 cites W2072881647 @default.
• W3027088372 cites W2076196097 @default.
• W3027088372 cites W2091588762 @default.
• W3027088372 cites W2100553071 @default.
• W3027088372 cites W2129774558 @default.
• W3027088372 cites W2131673797 @default.
• W3027088372 cites W2132028465 @default.
• W3027088372 cites W2155601605 @default.
• W3027088372 cites W2171613528 @default.
• W3027088372 cites W2197285997 @default.
• W3027088372 cites W2234428484 @default.
• W3027088372 cites W2298438588 @default.
• W3027088372 cites W2547187744 @default.
• W3027088372 cites W2612786119 @default.
• W3027088372 cites W2738833037 @default.
• W3027088372 cites W2800286951 @default.
• W3027088372 cites W2804784400 @default.
• W3027088372 cites W2889646458 @default.
• W3027088372 cites W2938255062 @default.
• W3027088372 cites W2938929416 @default.
• W3027088372 doi "https://doi.org/10.1016/j.chest.2020.04.068" @default.
• W3027088372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7545488" @default.
• W3027088372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32464188" @default.
• W3027088372 hasPublicationYear "2020" @default.
• W3027088372 type Work @default.
• W3027088372 sameAs 3027088372 @default.
• W3027088372 citedByCount "12" @default.
• W3027088372 countsByYear W30270883722021 @default.
• W3027088372 countsByYear W30270883722022 @default.
• W3027088372 countsByYear W30270883722023 @default.
• W3027088372 crossrefType "journal-article" @default.
• W3027088372 hasAuthorship W3027088372A5001098397 @default.
• W3027088372 hasAuthorship W3027088372A5003384343 @default.
• W3027088372 hasAuthorship W3027088372A5009108088 @default.
• W3027088372 hasAuthorship W3027088372A5009327463 @default.
• W3027088372 hasAuthorship W3027088372A5017638182 @default.
• W3027088372 hasAuthorship W3027088372A5020366697 @default.
• W3027088372 hasAuthorship W3027088372A5022481842 @default.
• W3027088372 hasAuthorship W3027088372A5022594161 @default.
• W3027088372 hasAuthorship W3027088372A5027783041 @default.
• W3027088372 hasAuthorship W3027088372A5028085268 @default.
• W3027088372 hasAuthorship W3027088372A5039844485 @default.
• W3027088372 hasAuthorship W3027088372A5044148216 @default.
• W3027088372 hasAuthorship W3027088372A5045973874 @default.
• W3027088372 hasAuthorship W3027088372A5046205786 @default.
• W3027088372 hasAuthorship W3027088372A5048608729 @default.
• W3027088372 hasAuthorship W3027088372A5063153537 @default.
• W3027088372 hasAuthorship W3027088372A5066240023 @default.
• W3027088372 hasAuthorship W3027088372A5073288035 @default.
• W3027088372 hasAuthorship W3027088372A5074644543 @default.
• W3027088372 hasAuthorship W3027088372A5082372978 @default.
• W3027088372 hasAuthorship W3027088372A5083208432 @default.
• W3027088372 hasAuthorship W3027088372A5088809839 @default.
• W3027088372 hasAuthorship W3027088372A5090485561 @default.
• W3027088372 hasBestOaLocation W30270883722 @default.
• W3027088372 hasConcept C104317684 @default.
• W3027088372 hasConcept C121608353 @default.
• W3027088372 hasConcept C126322002 @default.
• W3027088372 hasConcept C143998085 @default.
• W3027088372 hasConcept C16671776 @default.
• W3027088372 hasConcept C167135981 @default.
• W3027088372 hasConcept C2776256026 @default.
• W3027088372 hasConcept C501734568 @default.

• next