FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027128667> ?p ?o ?g. }

• W3027128667 endingPage "1881" @default.
• W3027128667 startingPage "1873" @default.
• W3027128667 abstract "Abstract Background Infant medulloblastoma represents an enormous challenge in neuro-oncology, due to their simultaneous high-risk of recurrence and high risk of severe neurodevelopmental sequelae with craniospinal irradiation. Currently infant medulloblastoma are treated with intensified protocols, either comprising intraventricular methotrexate or autologous transplant, both of which carry significant morbidity and are not feasible in the majority of the world. We sought to evaluate the molecular predictors of outcome in a cohort of infants homogeneously treated with induction chemotherapy, focal radiation and maintenance chemotherapy. Methods In a retrospective analysis, 29 young children treated with a craniospinal irradiation sparing strategy from Hospital Garrahan in Buenos Aires were profiled using Illumina HumanMethylationEPIC arrays, and correlated with survival. Results Twenty-nine children (range, 0.3–4.6 y) were identified, comprising 17 sonic hedgehog (SHH), 10 Group 3/4, and 2 non-medulloblastomas. Progression-free survival (PFS) across the entire cohort was 0.704 (95% CI: 0.551–0.899). Analysis by t-distributed stochastic neighbor embedding revealed 3 predominant groups, SHHβ, SHHγ, and Group 3. Survival by subtype was highly prognostic with SHHγ having an excellent 5-year PFS of 100% (95% CI: 0.633–1) and SHHβ having a PFS of 0.56 (95% CI: 0.42–1). Group 3 had a PFS of 0.50 (95% CI: 0.25–1). Assessment of neurocognitive outcome was performed in 11 patients; the majority of survivors fell within the low average to mild intellectual disability, with a median IQ of 73.5. Conclusions We report a globally feasible and effective strategy avoiding craniospinal radiation in the treatment of infant medulloblastoma, including a robust molecular correlation along with neurocognitive outcomes." @default.
• W3027128667 created "2020-05-29" @default.
• W3027128667 creator A5005657239 @default.
• W3027128667 creator A5010878596 @default.
• W3027128667 creator A5012736355 @default.
• W3027128667 creator A5015165140 @default.
• W3027128667 creator A5040263125 @default.
• W3027128667 creator A5040595262 @default.
• W3027128667 creator A5042327336 @default.
• W3027128667 creator A5046168756 @default.
• W3027128667 creator A5068257880 @default.
• W3027128667 creator A5073356790 @default.
• W3027128667 creator A5086885402 @default.
• W3027128667 creator A5088201399 @default.
• W3027128667 creator A5071526326 @default.
• W3027128667 date "2020-05-15" @default.
• W3027128667 modified "2023-10-16" @default.
• W3027128667 title "Bridging the treatment gap in infant medulloblastoma: molecularly informed outcomes of a globally feasible regimen" @default.
• W3027128667 cites W1576848373 @default.
• W3027128667 cites W1966157746 @default.
• W3027128667 cites W1966639599 @default.
• W3027128667 cites W1983718773 @default.
• W3027128667 cites W1986791919 @default.
• W3027128667 cites W1999013775 @default.
• W3027128667 cites W2021315589 @default.
• W3027128667 cites W2039379153 @default.
• W3027128667 cites W2043740625 @default.
• W3027128667 cites W2056485044 @default.
• W3027128667 cites W2057029910 @default.
• W3027128667 cites W2071064669 @default.
• W3027128667 cites W2077756022 @default.
• W3027128667 cites W2083527035 @default.
• W3027128667 cites W2099920119 @default.
• W3027128667 cites W2108582771 @default.
• W3027128667 cites W2122404743 @default.
• W3027128667 cites W2124272513 @default.
• W3027128667 cites W2124718678 @default.
• W3027128667 cites W2127643721 @default.
• W3027128667 cites W2135275068 @default.
• W3027128667 cites W2138746991 @default.
• W3027128667 cites W2160619817 @default.
• W3027128667 cites W2171473481 @default.
• W3027128667 cites W2334615503 @default.
• W3027128667 cites W2346627158 @default.
• W3027128667 cites W2492729867 @default.
• W3027128667 cites W2663954536 @default.
• W3027128667 cites W2794412782 @default.
• W3027128667 cites W2803132298 @default.
• W3027128667 cites W2809505594 @default.
• W3027128667 cites W2883035258 @default.
• W3027128667 cites W2884522547 @default.
• W3027128667 cites W2884819844 @default.
• W3027128667 cites W2913160740 @default.
• W3027128667 cites W2990858591 @default.
• W3027128667 cites W2991588978 @default.
• W3027128667 cites W3016851479 @default.
• W3027128667 doi "https://doi.org/10.1093/neuonc/noaa122" @default.
• W3027128667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7746938" @default.
• W3027128667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32413139" @default.
• W3027128667 hasPublicationYear "2020" @default.
• W3027128667 type Work @default.
• W3027128667 sameAs 3027128667 @default.
• W3027128667 citedByCount "10" @default.
• W3027128667 countsByYear W30271286672021 @default.
• W3027128667 countsByYear W30271286672022 @default.
• W3027128667 countsByYear W30271286672023 @default.
• W3027128667 crossrefType "journal-article" @default.
• W3027128667 hasAuthorship W3027128667A5005657239 @default.
• W3027128667 hasAuthorship W3027128667A5010878596 @default.
• W3027128667 hasAuthorship W3027128667A5012736355 @default.
• W3027128667 hasAuthorship W3027128667A5015165140 @default.
• W3027128667 hasAuthorship W3027128667A5040263125 @default.
• W3027128667 hasAuthorship W3027128667A5040595262 @default.
• W3027128667 hasAuthorship W3027128667A5042327336 @default.
• W3027128667 hasAuthorship W3027128667A5046168756 @default.
• W3027128667 hasAuthorship W3027128667A5068257880 @default.
• W3027128667 hasAuthorship W3027128667A5071526326 @default.
• W3027128667 hasAuthorship W3027128667A5073356790 @default.
• W3027128667 hasAuthorship W3027128667A5086885402 @default.
• W3027128667 hasAuthorship W3027128667A5088201399 @default.
• W3027128667 hasBestOaLocation W30271286671 @default.
• W3027128667 hasConcept C118552586 @default.
• W3027128667 hasConcept C126322002 @default.
• W3027128667 hasConcept C142724271 @default.
• W3027128667 hasConcept C143998085 @default.
• W3027128667 hasConcept C167135981 @default.
• W3027128667 hasConcept C169900460 @default.
• W3027128667 hasConcept C172467417 @default.
• W3027128667 hasConcept C185592680 @default.
• W3027128667 hasConcept C187212893 @default.
• W3027128667 hasConcept C207103383 @default.
• W3027128667 hasConcept C2776637008 @default.
• W3027128667 hasConcept C2776694085 @default.
• W3027128667 hasConcept C2780789225 @default.
• W3027128667 hasConcept C2781413609 @default.
• W3027128667 hasConcept C44249647 @default.
• W3027128667 hasConcept C55493867 @default.
• W3027128667 hasConcept C62478195 @default.

• next