FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027169439> ?p ?o ?g. }

• W3027169439 endingPage "11437" @default.
• W3027169439 startingPage "11425" @default.
• W3027169439 abstract "It is well known that microRNAs (miRNAs) are associated with tumor occurrence and development, and the functions of microRNA-22 (miR-22) have been investigated in numerous kinds of cancer. However, the significance of miR-22 in renal cell carcinoma (RCC) has not been fully explored. In this study, we found that miR-22 was down-regulated both in serum and tissues of RCC patients by using real time quantitative PCR (RT-qPCR) analyses. In addition, miR-22 was negatively associated with hepatic metastatic sites and lymphatic metastasis, as well as the clinical stages and prognosis. Moreover, the expression of miR-22 could be increased though surgical treatment in serum of RCC patients. Functional studies were performed to investigate the role of miR-22 in the progression of RCC. Data suggested that overexpression of miR-22 inhibited cell proliferation, migration and invasion in Caki-1 cells, whereas blockage of miR-22 could reverse these oncogenic effects. We also identified erb-b2 receptor tyrosine kinase (ERBB3) was a novel target of miR-22 in RCC cells. Consequently, our work provides evidence that the down-regulation of miR-22 expression contributed to RCC. And miR-22 may be a potential molecule biomarker for diagnose and therapy evaluation in RCC." @default.
• W3027169439 created "2020-05-29" @default.
• W3027169439 creator A5014234588 @default.
• W3027169439 creator A5034169829 @default.
• W3027169439 creator A5090654210 @default.
• W3027169439 date "2017-01-01" @default.
• W3027169439 modified "2023-09-23" @default.
• W3027169439 title "MiR-22 functions as a biomarker and regulates cell proliferation, cycle, apoptosis, migration and invasion in renal cell carcinoma." @default.
• W3027169439 cites W1975304818 @default.
• W3027169439 cites W1975437957 @default.
• W3027169439 cites W1987977871 @default.
• W3027169439 cites W1992478590 @default.
• W3027169439 cites W2005154499 @default.
• W3027169439 cites W2024162065 @default.
• W3027169439 cites W2034561062 @default.
• W3027169439 cites W2055818547 @default.
• W3027169439 cites W2056030683 @default.
• W3027169439 cites W2065418531 @default.
• W3027169439 cites W2111503975 @default.
• W3027169439 cites W2115093090 @default.
• W3027169439 cites W2120137028 @default.
• W3027169439 cites W2129407204 @default.
• W3027169439 cites W2138015614 @default.
• W3027169439 cites W2149146453 @default.
• W3027169439 cites W2151922790 @default.
• W3027169439 cites W2177729419 @default.
• W3027169439 cites W2188142363 @default.
• W3027169439 cites W2318370472 @default.
• W3027169439 cites W2434847197 @default.
• W3027169439 cites W2517907818 @default.
• W3027169439 cites W2521338769 @default.
• W3027169439 cites W2566478516 @default.
• W3027169439 cites W2583633591 @default.
• W3027169439 cites W2590925693 @default.
• W3027169439 cites W2592290961 @default.
• W3027169439 cites W2594592457 @default.
• W3027169439 cites W2599164481 @default.
• W3027169439 cites W2917837889 @default.
• W3027169439 cites W3023299375 @default.
• W3027169439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6966068" @default.
• W3027169439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31966498" @default.
• W3027169439 hasPublicationYear "2017" @default.
• W3027169439 type Work @default.
• W3027169439 sameAs 3027169439 @default.
• W3027169439 citedByCount "1" @default.
• W3027169439 countsByYear W30271694392023 @default.
• W3027169439 crossrefType "journal-article" @default.
• W3027169439 hasAuthorship W3027169439A5014234588 @default.
• W3027169439 hasAuthorship W3027169439A5034169829 @default.
• W3027169439 hasAuthorship W3027169439A5090654210 @default.
• W3027169439 hasConcept C101544691 @default.
• W3027169439 hasConcept C104317684 @default.
• W3027169439 hasConcept C115456853 @default.
• W3027169439 hasConcept C121608353 @default.
• W3027169439 hasConcept C126322002 @default.
• W3027169439 hasConcept C137738243 @default.
• W3027169439 hasConcept C142724271 @default.
• W3027169439 hasConcept C145059251 @default.
• W3027169439 hasConcept C1491633281 @default.
• W3027169439 hasConcept C190283241 @default.
• W3027169439 hasConcept C2777472916 @default.
• W3027169439 hasConcept C2779013556 @default.
• W3027169439 hasConcept C2781197716 @default.
• W3027169439 hasConcept C29537977 @default.
• W3027169439 hasConcept C502942594 @default.
• W3027169439 hasConcept C54355233 @default.
• W3027169439 hasConcept C55493867 @default.
• W3027169439 hasConcept C62112901 @default.
• W3027169439 hasConcept C62478195 @default.
• W3027169439 hasConcept C71924100 @default.
• W3027169439 hasConcept C86803240 @default.
• W3027169439 hasConcept C95444343 @default.
• W3027169439 hasConceptScore W3027169439C101544691 @default.
• W3027169439 hasConceptScore W3027169439C104317684 @default.
• W3027169439 hasConceptScore W3027169439C115456853 @default.
• W3027169439 hasConceptScore W3027169439C121608353 @default.
• W3027169439 hasConceptScore W3027169439C126322002 @default.
• W3027169439 hasConceptScore W3027169439C137738243 @default.
• W3027169439 hasConceptScore W3027169439C142724271 @default.
• W3027169439 hasConceptScore W3027169439C145059251 @default.
• W3027169439 hasConceptScore W3027169439C1491633281 @default.
• W3027169439 hasConceptScore W3027169439C190283241 @default.
• W3027169439 hasConceptScore W3027169439C2777472916 @default.
• W3027169439 hasConceptScore W3027169439C2779013556 @default.
• W3027169439 hasConceptScore W3027169439C2781197716 @default.
• W3027169439 hasConceptScore W3027169439C29537977 @default.
• W3027169439 hasConceptScore W3027169439C502942594 @default.
• W3027169439 hasConceptScore W3027169439C54355233 @default.
• W3027169439 hasConceptScore W3027169439C55493867 @default.
• W3027169439 hasConceptScore W3027169439C62112901 @default.
• W3027169439 hasConceptScore W3027169439C62478195 @default.
• W3027169439 hasConceptScore W3027169439C71924100 @default.
• W3027169439 hasConceptScore W3027169439C86803240 @default.
• W3027169439 hasConceptScore W3027169439C95444343 @default.
• W3027169439 hasIssue "12" @default.
• W3027169439 hasLocation W30271694391 @default.
• W3027169439 hasOpenAccess W3027169439 @default.
• W3027169439 hasPrimaryLocation W30271694391 @default.

• next