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- W3027189784 endingPage "1755" @default.
- W3027189784 startingPage "1740" @default.
- W3027189784 abstract "Baclofen, β-(4-chlorophenyl)-γ-aminobutyric acid, holds a unique position in neuroscience, remaining the only U.S. Food and Drug Administration (FDA) approved GABAB agonist. While intended to be a more brain penetrant, i.e, ability to cross the blood-brain barrier (BBB), version of GABA (γ-aminobutyric acid) for the potential treatment of epilepsy, baclofen's highly efficacious muscle relaxant properties led to its approval, as a racemate, for the treatment of spasticity. Interestingly, baclofen received FDA approval before its receptor, GABAB, was discovered and its exact mechanism of action was known. In recent times, baclofen has a myriad of off-label uses, with the treatment for alcohol abuse and drug addiction garnering a great deal of attention. This Review aims to capture the >60 year legacy of baclofen by walking through the history, pharmacology, synthesis, drug metabolism, routes of administration, and societal impact of this Classic in chemical neuroscience." @default.
- W3027189784 created "2020-05-29" @default.
- W3027189784 creator A5018203361 @default.
- W3027189784 creator A5060483072 @default.
- W3027189784 creator A5076518886 @default.
- W3027189784 date "2020-05-21" @default.
- W3027189784 modified "2023-09-23" @default.
- W3027189784 title "Classics in Chemical Neuroscience: Baclofen" @default.
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